Homo sapiens Gene: MSH5
Summary
InnateDB Gene IDBG-78972.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MSH5
Gene Name mutS homolog 5 (E. coli)
Synonyms G7; MUTSH5; NG23;
Species Homo sapiens
Ensembl Gene ENSG00000204410
Encoded Proteins
mutS homolog 5 (E. coli)
mutS homolog 5 (E. coli)
mutS homolog 5 (E. coli)
mutS homolog 5 (E. coli)
mutS homolog 5 (E. coli)
mutS homolog 5 (E. coli)
mutS homolog 5 (E. coli)
mutS homolog 5 (E. coli)
mutS homolog 5 (E. coli)
mutS homolog 5 (E. coli)
mutS homolog 5 (E. coli)
mutS homolog 5 (E. coli)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This locus represents naturally occurring read-through transcription between the neighboring mutS homolog 5 (MSH5) and chromosome 6 open reading frame 26 (C6orf26) genes. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. [provided by RefSeq, Feb 2011] This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. [provided by RefSeq, Feb 2011]
This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:31739948-31762834
Strand Forward strand
Band p21.33
Transcripts
ENST00000375755 ENSP00000364908
ENST00000375750 ENSP00000364903
ENST00000375740 ENSP00000364892
ENST00000375703 ENSP00000364855
ENST00000395853 ENSP00000379194
ENST00000425703 ENSP00000402842
ENST00000423982 ENSP00000406352
ENST00000450148 ENSP00000394971
ENST00000429846 ENSP00000406849
ENST00000463094
ENST00000482280
ENST00000463144 ENSP00000419648
ENST00000497269 ENSP00000419131
ENST00000468602
ENST00000468136
ENST00000467319
ENST00000494646
ENST00000484309 ENSP00000420232
ENST00000494458
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 DNA-dependent ATPase activity
GO:0030983 mismatched DNA binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006298 mismatch repair
GO:0007126 meiotic nuclear division
GO:0007131 reciprocal meiotic recombination
GO:0007136 meiotic prophase II
GO:0045143 homologous chromosome segregation
GO:0051026 chiasma assembly
Cellular Component
GO:0000795 synaptonemal complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cell Cycle pathway
Meiotic recombination pathway
Meiosis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_002441 NM_025259 NM_172165 NM_172166
HUGO
OMIM
CCDS CCDS34409 CCDS34410 CCDS4720
HPRD 04544
IMGT
EMBL
GenPept
RNA Seq Atlas