InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MSH5

Summary

InnateDB Protein

IDBP-78984.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MSH5

Protein Name

mutS homolog 5 (E. coli)

Synonyms

G7; MUTSH5; NG23;

Species

Homo sapiens

Ensembl Protein

ENSP00000364855

InnateDB Gene

IDBG-78972 (MSH5)

Protein Structure

UniProt Annotation

Function

Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Ubiquitous, but highly expressed in testis, and thymus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008094	DNA-dependent ATPase activity
GO:0030983	mismatched DNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006298	mismatch repair
GO:0007126	meiotic nuclear division
GO:0007131	reciprocal meiotic recombination
GO:0007136	meiotic prophase II
GO:0045143	homologous chromosome segregation
GO:0051026	chiasma assembly

Cellular Component

GO:0000795

synaptonemal complex

Protein Structure and Domains

PDB ID

InterPro

IPR000432 DNA mismatch repair protein MutS, C-terminal
IPR007696 DNA mismatch repair protein MutS, core
IPR007861 DNA mismatch repair protein MutS, clamp
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00488
PF05192
PF05190

PRINTS

PIRSF

SMART

SM00534
SM00533

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O43196