Homo sapiens Gene: KAT6B
Summary
InnateDB Gene IDBG-79073.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KAT6B
Gene Name K(lysine) acetyltransferase 6B
Synonyms GTPTS; MORF; MOZ2; MYST4; qkf; querkopf; ZC2HC6B;
Species Homo sapiens
Ensembl Gene ENSG00000156650
Encoded Proteins
K(lysine) acetyltransferase 6B
K(lysine) acetyltransferase 6B
K(lysine) acetyltransferase 6B
K(lysine) acetyltransferase 6B
K(lysine) acetyltransferase 6B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:74825582-75032622
Strand Forward strand
Band q22.2
Transcripts
ENST00000372725 ENSP00000361810
ENST00000372724 ENSP00000361809
ENST00000287239 ENSP00000287239
ENST00000372714 ENSP00000361799
ENST00000372711 ENSP00000361796
ENST00000490365
ENST00000604130
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0016407 acetyltransferase activity
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
Biological Process
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0016573 histone acetylation
GO:0043966 histone H3 acetylation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0070776 MOZ/MORF histone acetyltransferase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
HATs acetylate histones pathway
Chromatin organization pathway
Chromatin modifying enzymes pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q8WYB5
TrEMBL
UniProt Splice Variant
Entrez Gene 23522
UniGene Hs.35758
RefSeq NM_001256469 NM_001256468 NM_012330 XM_005269664
HUGO HGNC:17582
OMIM 605880
CCDS CCDS58084 CCDS58085 CCDS7345
HPRD 07065
IMGT
EMBL AB002381 AF113514 AF119230 AF119231 AF217500 BC014143 BC021128 BC048199
GenPept AAF00095 AAF00099 AAF00100 AAH14143 AAH21128 AAH48199 AAL56647 BAA20837
RNA Seq Atlas 23522