Version 5.4
Mus musculus Gene: Myst4
Summary
InnateDB Gene IDBG-137188.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Myst4
Gene Name MYST histone acetyltransferase monocytic leukemia 4
Synonyms AI507552; B130044K16Rik; mKIAA0383; Morf; MYST-4; Myst4; qkf; querkopf
Species Mus musculus
Ensembl Gene ENSMUSG00000021767
Encoded Proteins
IDBP-137190
MYST histone acetyltransferase monocytic leukemia 4
IDBP-255989
MYST histone acetyltransferase monocytic leukemia 4
IDBP-790247
K(lysine) acetyltransferase 6B
IDBP-790248
K(lysine) acetyltransferase 6B
IDBP-790249
K(lysine) acetyltransferase 6B
IDBP-790250
K(lysine) acetyltransferase 6B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156650:
The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:21481434-21672478
Strand Forward strand
Band A3
Transcripts
ENSMUST00000069648 ENSMUSP00000066693
ENSMUST00000096222
ENSMUST00000112458 ENSMUSP00000108077
ENSMUST00000182996 ENSMUSP00000138746
ENSMUST00000183201
ENSMUST00000182855 ENSMUSP00000138511
ENSMUST00000182859
ENSMUST00000182405 ENSMUSP00000138377
ENSMUST00000183228
ENSMUST00000183055
ENSMUST00000182964 ENSMUSP00000138421
ENSMUST00000182553
ENSMUST00000182732
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0016407 acetyltransferase activity
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
Biological Process
GO:0006334 nucleosome assembly
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0016573 histone acetylation
GO:0043966 histone H3 acetylation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0070776 MOZ/MORF histone acetyltransferase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000156650
View Gene Order
ENSBTAG00000002920
Not yet available
Pathways
NETPATH
REACTOME
REACT_218274
Chromatin organization pathway
REACT_226917
HATs acetylate histones pathway
REACT_202766
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_172610
HATs acetylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8BRB7
TrEMBL S4R2Q8
UniProt Splice Variant
Entrez Gene 54169
UniGene Mm.471076
RefSeq NM_001205241 NM_017479 XM_006519268 XM_006519270
OMIM
CCDS CCDS59615
HPRD
IMGT
MGI ID MGI:1858746
MGI Symbol Kat6b
EMBL AC115122 AC148978 AF222800 AK045188 AK048336 AK052307 AK083123 AY294423
GenPept AAF26744 AAQ01512 BAC32253 BAC33305 BAC34930 BAC38771
RNA Seq Atlas 54169

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca