Version 5.4
Homo sapiens Gene: CD28
Summary
InnateDB Gene IDBG-79183.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD28
Gene Name CD28 molecule
Synonyms Tp44
Species Homo sapiens
Ensembl Gene ENSG00000178562
Encoded Proteins
IDBP-79185
CD28 molecule
IDBP-79189
CD28 molecule
IDBP-388507
CD28 molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:203706475-203738912
Strand Forward strand
Band q33.2
Transcripts
ENST00000374481 ENSP00000363605
ENST00000324106 ENSP00000324890
ENST00000458610 ENSP00000393648
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
GO:0015026 coreceptor activity
GO:0042802 identical protein binding
Biological Process
GO:0002863 positive regulation of inflammatory response to antigenic stimulus
GO:0006959 humoral immune response
GO:0007166 cell surface receptor signaling pathway
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009967 positive regulation of signal transduction
GO:0016032 viral process
GO:0031295 T cell costimulation
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042089 cytokine biosynthetic process
GO:0042102 positive regulation of T cell proliferation
GO:0045060 negative thymic T cell selection
GO:0045066 regulatory T cell differentiation
GO:0045070 positive regulation of viral genome replication
GO:0045086 positive regulation of interleukin-2 biosynthetic process
GO:0045087 innate immune response
GO:0045727 positive regulation of translation
GO:0045840 positive regulation of mitosis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0050690 regulation of defense response to virus by virus
GO:0050852 T cell receptor signaling pathway
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0001772 immunological synapse
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026012
View Gene Order
ENSBTAG00000007445
Not yet available
Pathways
NETPATH
NetPath_11
TCR pathway
REACTOME
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_19358
CD28 dependent PI3K/Akt signaling pathway
REACT_19238
CD28 dependent Vav1 pathway pathway
REACT_19183
CD28 co-stimulation pathway
REACT_19344
Costimulation by the CD28 family pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_11139
Nef mediated downregulation of CD28 cell surface expression pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_11149
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_6185
HIV Infection pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_6835
The role of Nef in HIV-1 replication and disease pathogenesis pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04940
Type I diabetes mellitus pathway
hsa04660
T cell receptor signaling pathway pathway
hsa05330
Allograft rejection pathway
hsa05320
Autoimmune thyroid disease pathway
hsa05322
Systemic lupus erythematosus pathway
hsa05332
Graft-versus-host disease pathway
hsa04672
Intestinal immune network for IgA production pathway
hsa05416
Viral myocarditis pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
PID NCI
cd8tcrpathway
TCR signaling in naïve CD8+ T cells
tcr_pathway
TCR signaling in naïve CD4+ T cells
il12_stat4pathway
IL12 signaling mediated by STAT4
Cross-References
SwissProt P10747
TrEMBL
UniProt Splice Variant
Entrez Gene 940
UniGene Hs.1987 Hs.443123
RefSeq NM_001243078 NM_001243077 NM_006139 XM_006712862
HUGO HGNC:1653
OMIM 186760
CCDS CCDS58749 CCDS2361
HPRD 01727
IMGT
EMBL AC125238 AF222341 AF222342 AF222343 AF411057 AJ295273 AJ517504 AK292986 AK313313 BC093698 BC112085 CH471063 EF064755 J02988 M37812 M37813 M37814 M37815
GenPept AAA51944 AAA51945 AAA60581 AAF33792 AAF33793 AAF33794 AAH93698 AAI12086 AAL40931 AAY24123 ABK41938 BAF85675 BAG36118 CAC29237 CAD57003 EAW70348
RNA Seq Atlas 940

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca