Version 5.4
Homo sapiens Protein: CD28
Summary
InnateDB Protein IDBP-79185.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD28
Protein Name CD28 molecule
Synonyms Tp44;
Species Homo sapiens
Ensembl Protein ENSP00000363605
InnateDB Gene IDBG-79183 (CD28)
Protein Structure
UniProt Annotation
Function Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.
Subcellular Localization Membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity Expressed in T-cells and plasma cells, but not in less mature B-cells.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
GO:0015026 coreceptor activity
GO:0042802 identical protein binding
Biological Process
GO:0006959 humoral immune response
GO:0007166 cell surface receptor signaling pathway
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009967 positive regulation of signal transduction
GO:0016032 viral process
GO:0031295 T cell costimulation
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042089 cytokine biosynthetic process
GO:0042102 positive regulation of T cell proliferation
GO:0045066 regulatory T cell differentiation
GO:0045070 positive regulation of viral genome replication
GO:0045086 positive regulation of interleukin-2 biosynthetic process
GO:0045087 innate immune response
GO:0045727 positive regulation of translation
GO:0045840 positive regulation of mitosis
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050690 regulation of defense response to virus by virus
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR008093 T cell antigen CD28
PFAM
PRINTS PR01717
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P10747
PhosphoSite PhosphoSite-P10747
TrEMBL
UniProt Splice Variant
Entrez Gene 940
UniGene Hs.443123
RefSeq NP_001230007
HUGO HGNC:1653
OMIM 186760
CCDS CCDS58749
HPRD 01727
IMGT
EMBL AC125238 AF222341 AF222342 AF222343 AF411057 AJ295273 AJ517504 AK292986 AK313313 BC093698 BC112085 CH471063 EF064755 J02988 M37812 M37813 M37814 M37815
GenPept AAA51944 AAA51945 AAA60581 AAF33792 AAF33793 AAF33794 AAH93698 AAI12086 AAL40931 AAY24123 ABK41938 BAF85675 BAG36118 CAC29237 CAD57003 EAW70348

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca