Homo sapiens Gene: SLC13A3
Summary
InnateDB Gene IDBG-79300.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC13A3
Gene Name solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000158296
Encoded Proteins
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:46557823-46684467
Strand Reverse strand
Band q13.12
Transcripts
ENST00000290317 ENSP00000290317
ENST00000279027 ENSP00000279027
ENST00000372121 ENSP00000361193
ENST00000413164 ENSP00000415852
ENST00000450298 ENSP00000394217
ENST00000420568 ENSP00000395095
ENST00000417157 ENSP00000397955
ENST00000472148 ENSP00000420177
ENST00000495082 ENSP00000419621
ENST00000468915 ENSP00000417784
ENST00000464518
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0015362 high affinity sodium:dicarboxylate symporter activity
Biological Process
GO:0006814 sodium ion transport
GO:0006835 dicarboxylic acid transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Sodium-coupled sulphate, di- and tri-carboxylate transporters pathway
SLC-mediated transmembrane transport pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.602163 Hs.655498 Hs.670365
RefSeq NM_001011554 NM_001193339 NM_001193340 NM_001193342 NM_022829
HUGO
OMIM
CCDS CCDS13400 CCDS42886 CCDS54469 CCDS54470
HPRD 10450
IMGT
EMBL
GenPept
RNA Seq Atlas