Version 5.4
Homo sapiens Gene: EHMT2
Summary
InnateDB Gene IDBG-79489.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EHMT2
Gene Name euchromatic histone-lysine N-methyltransferase 2
Synonyms BAT8; C6orf30; G9A; GAT8; KMT1C; NG36
Species Homo sapiens
Ensembl Gene ENSG00000204371
Encoded Proteins
IDBP-79491
euchromatic histone-lysine N-methyltransferase 2
IDBP-79493
euchromatic histone-lysine N-methyltransferase 2
IDBP-79495
euchromatic histone-lysine N-methyltransferase 2
IDBP-238926
euchromatic histone-lysine N-methyltransferase 2
IDBP-373307
euchromatic histone-lysine N-methyltransferase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22412156
EHMT2 catalyzes di-methylation of histone H3 at the promoter of interferon (IFN) and IFN-inducible antiviral genes as an epigenetic silencing mechanism in fibroblasts. Ablation of EHMT2 results in phenotypic conversion to potent IFN-producing cells and renders resistance to RNA viruses. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
PMID 22412156
[Mus musculus] Ehmt2 catalyzes di-methylation of histone H3 at the promoter of interferon (IFN) and IFN-inducible antiviral genes as an epigenetic silencing mechanism in fibroblasts. Ablation of Ehmt2 results in phenotypic conversion to potent IFN-producing cells and renders resistance to RNA viruses.
Entrez Gene
Summary A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. This gene is found near this cluster; it was mapped near the gene for C2 within a 120-kb region that included a HSP70 gene pair. These genes are all within the human major histocompatibility complex class III region. This gene was thought to be two different genes, NG36 and G9a, adjacent to each other but a recent publication shows that there is only a single gene. The protein encoded by this gene is thought to be involved in intracellular protein-protein interaction. There are three alternatively spliced transcript variants of this gene but only two are fully described. [provided by RefSeq, Jul 2008]
This gene is located in a gene cluster within the human major histocompatibility complex class III region on chromosome 6. This gene was thought to be two different genes, NG36 and G9a, adjacent to each other but recent publications show that there is only a single gene at this locus. The encoded protein is a histone methyltransferase, which may be involved in repression of transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:31879759-31897687
Strand Reverse strand
Band p21.33
Transcripts
ENST00000375537 ENSP00000364687
ENST00000375530 ENSP00000364680
ENST00000375528 ENSP00000364678
ENST00000395728 ENSP00000379078
ENST00000436026 ENSP00000412353
ENST00000478491
ENST00000461880
ENST00000494816
ENST00000480912
ENST00000477678
ENST00000463484
ENST00000465429
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 117 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 117 [view]
Protein-Protein 113 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002039 p53 binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016279 protein-lysine N-methyltransferase activity
GO:0018024 histone-lysine N-methyltransferase activity
GO:0046974 histone methyltransferase activity (H3-K9 specific)
GO:0046976 histone methyltransferase activity (H3-K27 specific)
GO:0070742 C2H2 zinc finger domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006275 regulation of DNA replication
GO:0006306 DNA methylation
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007130 synaptonemal complex assembly
GO:0007281 germ cell development
GO:0007286 spermatid development
GO:0009566 fertilization
GO:0010424 DNA methylation on cytosine within a CG sequence
GO:0016571 histone methylation
GO:0018027 peptidyl-lysine dimethylation
GO:0034968 histone lysine methylation
GO:0035265 organ growth
GO:0045087 innate immune response (InnateDB)
GO:0051567 histone H3-K9 methylation
GO:0070734 histone H3-K27 methylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000013787
View Gene Order
ENSBTAG00000005676
Not yet available
Pathways
NETPATH
REACTOME
REACT_953
RNA Polymerase I Transcription Initiation pathway
REACT_120956
Cellular responses to stress pathway
REACT_1309
RNA Polymerase I Transcription pathway
REACT_1974
RNA Polymerase I Promoter Clearance pathway
REACT_169274
Cellular Senescence pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_169168
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_71
Gene Expression pathway
KEGG
hsa00310
Lysine degradation pathway
INOH
PID NCI
ar_tf_pathway
Regulation of Androgen receptor activity
Cross-References
SwissProt Q96KQ7
TrEMBL A0A024RCN9 A2ABF8 A2ABF9
UniProt Splice Variant
Entrez Gene 10919
UniGene Hs.520038 Hs.709218
RefSeq NM_001289413 NM_006709 NM_025256 XM_005248824 XM_005272767 XM_005274913 XM_006714974 XM_006714975 XM_006725467 XM_006725468 XM_006725682 XM_006725683
HUGO HGNC:14129
OMIM 604599
CCDS CCDS4725 CCDS4726 CCDS75425
HPRD
IMGT
EMBL AF134726 AJ315532 AK056936 AL662834 AL671762 AL844853 BA000025 BC002686 BC009351 BC018718 BC020970 CH471081 CR388202 CR388219 CR759784 CR936237 X69838
GenPept AAD21811 AAD21812 AAH02686 AAH09351 AAH18718 AAH20970 BAB63294 BAB63295 BAB71314 CAA49491 CAC86666 CAI17747 CAI17748 CAI18224 CAI18226 CAI41852 CAI41853 CAQ07473 CAQ07474 CAQ09159 CAQ09311 CAQ09508 CAQ09509 EAX03542 EAX03544
RNA Seq Atlas 102724277 10919

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca