Homo sapiens Gene: FZD5
Summary
InnateDB Gene IDBG-79672.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FZD5
Gene Name frizzled family receptor 5
Synonyms C2orf31; HFZ5;
Species Homo sapiens
Ensembl Gene ENSG00000163251
Encoded Proteins
frizzled family receptor 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand. [provided by RefSeq, Jul 2008]
Members of the \'frizzled\' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:207762586-207769563
Strand Reverse strand
Band q33.3
Transcripts
ENST00000295417 ENSP00000354607
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 15 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0017147 Wnt-protein binding
GO:0019901 protein kinase binding
GO:0030165 PDZ domain binding
GO:0031625 ubiquitin protein ligase binding
GO:0042813 Wnt-activated receptor activity
Biological Process
GO:0000578 embryonic axis specification
GO:0001525 angiogenesis
GO:0001944 vasculature development
GO:0006915 apoptotic process
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007409 axonogenesis
GO:0007420 brain development
GO:0008285 negative regulation of cell proliferation
GO:0008406 gonad development
GO:0008595 anterior/posterior axis specification, embryo
GO:0016055 Wnt signaling pathway
GO:0030182 neuron differentiation
GO:0031076 embryonic camera-type eye development
GO:0031077 post-embryonic camera-type eye development
GO:0032729 positive regulation of interferon-gamma production
GO:0033077 T cell differentiation in thymus
GO:0043507 positive regulation of JUN kinase activity
GO:0044332 Wnt signaling pathway involved in dorsal/ventral axis specification
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048469 cell maturation
GO:0060061 Spemann organizer formation
GO:0060070 canonical Wnt signaling pathway
GO:0060561 apoptotic process involved in morphogenesis
GO:0060670 branching involved in labyrinthine layer morphogenesis
GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development
GO:0060716 labyrinthine layer blood vessel development
GO:0060718 chorionic trophoblast cell differentiation
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0071219 cellular response to molecule of bacterial origin
GO:1901382 regulation of chorionic trophoblast cell proliferation
GO:2000810 regulation of tight junction assembly
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0042995 cell projection
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Wnt pathway
REACTOME
PCP/CE pathway pathway
Ca2+ pathway pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Signaling by GPCR pathway
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
Signal Transduction pathway
regulation of FZD by ubiquitination pathway
TCF dependent signaling in response to WNT pathway
Asymmetric localization of PCP proteins pathway
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
GPCR ligand binding pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Class B/2 (Secretin family receptors) pathway
Disease pathway
KEGG
Wnt signaling pathway pathway
Melanogenesis pathway
Pathways in cancer pathway
Basal cell carcinoma pathway
INOH
GPCR signaling pathway
Wnt signaling pathway pathway
PID BIOCARTA
PID NCI
Wnt signaling network
Canonical Wnt signaling pathway
Degradation of beta catenin
Cross-References
SwissProt Q13467
TrEMBL
UniProt Splice Variant
Entrez Gene 7855
UniGene Hs.17631 Hs.602599 Hs.609782 Hs.698624
RefSeq NM_003468
HUGO HGNC:4043
OMIM 601723
CCDS CCDS33366
HPRD 03427
IMGT
EMBL AB043702 AC096772 AK290386 AK315338 U43318
GenPept AAC50385 AAY24058 BAB60959 BAF83075 BAG37738
RNA Seq Atlas 7855