Version 5.4
Bos taurus Gene: FZD5
Summary
InnateDB Gene IDBG-647764.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FZD5
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000020957
Encoded Proteins
IDBP-700562
frizzled family receptor 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163251:
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand. [provided by RefSeq, Jul 2008]
Members of the \'frizzled\' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:96470387-96472144
Strand Reverse strand
Band
Transcripts
ENSBTAT00000027911 ENSBTAP00000041785
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0017147 Wnt-protein binding
GO:0019901 protein kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042813 Wnt-activated receptor activity
Biological Process
GO:0000578 embryonic axis specification
GO:0001525 angiogenesis
GO:0001944 vasculature development
GO:0007166 cell surface receptor signaling pathway
GO:0007275 multicellular organismal development
GO:0008285 negative regulation of cell proliferation
GO:0008595 anterior/posterior axis specification, embryo
GO:0016055 Wnt signaling pathway
GO:0031076 embryonic camera-type eye development
GO:0031077 post-embryonic camera-type eye development
GO:0032729 positive regulation of interferon-gamma production
GO:0033077 T cell differentiation in thymus
GO:0043507 positive regulation of JUN kinase activity
GO:0044332 Wnt signaling pathway involved in dorsal/ventral axis specification
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048469 cell maturation
GO:0060061 Spemann organizer formation
GO:0060070 canonical Wnt signaling pathway
GO:0060561 apoptotic process involved in morphogenesis
GO:0060670 branching involved in labyrinthine layer morphogenesis
GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development
GO:0060716 labyrinthine layer blood vessel development
GO:0060718 chorionic trophoblast cell differentiation
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0071219 cellular response to molecule of bacterial origin
GO:1901382 regulation of chorionic trophoblast cell proliferation
GO:2000810 regulation of tight junction assembly
Cellular Component
GO:0005769 early endosome
GO:0005794 Golgi apparatus
GO:0005923 tight junction
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000163251
View Gene Order
ENSMUSG00000045005
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_8
Wnt pathway
REACTOME
REACT_18372
Class B/2 (Secretin family receptors) pathway
REACT_172581
PCP/CE pathway pathway
REACT_172761
Ca2+ pathway pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_14797
Signaling by GPCR pathway
REACT_200610
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
REACT_111102
Signal Transduction pathway
REACT_200716
regulation of FZD by ubiquitination pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_172638
Asymmetric localization of PCP proteins pathway
REACT_172631
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_21340
GPCR ligand binding pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_116125
Disease pathway
REACT_222715
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 pathway
REACT_189085
Disease pathway
REACT_214014
Signaling by Wnt pathway
REACT_254215
Signaling by GPCR pathway
REACT_250061
Class B/2 (Secretin family receptors) pathway
REACT_233046
Signaling by WNT in cancer pathway
REACT_226355
beta-catenin independent WNT signaling pathway
REACT_262115
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_214043
PCP/CE pathway pathway
REACT_241644
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_216784
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
REACT_207044
TCF dependent signaling in response to WNT pathway
REACT_231468
GPCR ligand binding pathway
REACT_221970
Ca2+ pathway pathway
REACT_203973
Asymmetric localization of PCP proteins pathway
REACT_188257
Signal Transduction pathway
REACT_241402
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
hsa04310
Wnt signaling pathway pathway
hsa05217
Basal cell carcinoma pathway
hsa04916
Melanogenesis pathway
hsa05200
Pathways in cancer pathway
mmu05217
Basal cell carcinoma pathway
mmu04916
Melanogenesis pathway
mmu04310
Wnt signaling pathway pathway
mmu05200
Pathways in cancer pathway
INOH
INOH website
Wnt signaling pathway pathway
INOH website
GPCR signaling pathway
INOH website
Wnt signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
wnt_signaling_pathway
Wnt signaling network
wnt_canonical_pathway
Canonical Wnt signaling pathway
betacatenin_deg_pathway
Degradation of beta catenin
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.87182
RefSeq XM_005197510 XM_005197511 XM_005197512 XM_005202766 XM_005202767 XM_005202768
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca