Homo sapiens Gene: ACTL7B
Summary
InnateDB Gene IDBG-79867.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACTL7B
Gene Name actin-like 7B
Synonyms Tact1;
Species Homo sapiens
Ensembl Gene ENSG00000148156
Encoded Proteins
actin-like 7B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7B), and related gene, ACTL7A, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7B gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. Unlike ACTL7A, the ACTL7B gene is expressed predominantly in the testis, however, its exact function is not known. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:108854589-108856967
Strand Reverse strand
Band q31.3
Transcripts
ENST00000374667 ENSP00000363799
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005200 structural constituent of cytoskeleton
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0015629 actin cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q9Y614
TrEMBL
UniProt Splice Variant
Entrez Gene 10880
UniGene Hs.534390
RefSeq NM_006686
HUGO HGNC:162
OMIM 604304
CCDS CCDS6771
HPRD
IMGT
EMBL AB284521 AF113527 AK313871 AL359692 BC033789 CH471105
GenPept AAD44110 AAH33789 BAF41972 BAG36599 CAI40570 EAW59025
RNA Seq Atlas 10880