Homo sapiens Gene: ACADL
Summary
InnateDB Gene IDBG-79903.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACADL
Gene Name acyl-CoA dehydrogenase, long chain
Synonyms ACAD4; LCAD;
Species Homo sapiens
Ensembl Gene ENSG00000115361
Encoded Proteins
acyl-CoA dehydrogenase, long chain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyze the initial step of mitochondrial beta-oxidation of straight-chain fatty acid. Defects in this gene are the cause of long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycemia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:210187939-210225491
Strand Reverse strand
Band q34
Transcripts
ENST00000233710 ENSP00000233710
ENST00000482502
ENST00000498120
ENST00000482523
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000062 fatty-acyl-CoA binding
GO:0003995 acyl-CoA dehydrogenase activity
GO:0004466 long-chain-acyl-CoA dehydrogenase activity
GO:0016401 palmitoyl-CoA oxidase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0001659 temperature homeostasis
GO:0006635 fatty acid beta-oxidation
GO:0008152 metabolic process
GO:0019254 carnitine metabolic process, CoA-linked
GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0042413 carnitine catabolic process
GO:0042758 long-chain fatty acid catabolic process
GO:0044242 cellular lipid catabolic process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045717 negative regulation of fatty acid biosynthetic process
GO:0046322 negative regulation of fatty acid oxidation
GO:0051289 protein homotetramerization
GO:0055114 oxidation-reduction process
GO:0090181 regulation of cholesterol metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0031966 mitochondrial membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA pathway
Mitochondrial Fatty Acid Beta-Oxidation pathway
Beta oxidation of myristoyl-CoA to lauroyl-CoA pathway
mitochondrial fatty acid beta-oxidation of saturated fatty acids pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
KEGG
Fatty acid degradation pathway
PPAR signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.471277
RefSeq NM_001608
HUGO
OMIM
CCDS CCDS2389
HPRD 01939
IMGT
EMBL
GenPept
RNA Seq Atlas