Version 5.4
Homo sapiens Gene: ACADL
Summary
InnateDB Gene IDBG-79903.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACADL
Gene Name acyl-CoA dehydrogenase, long chain
Synonyms ACAD4; LCAD
Species Homo sapiens
Ensembl Gene ENSG00000115361
Encoded Proteins
IDBP-79905
acyl-CoA dehydrogenase, long chain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyze the initial step of mitochondrial beta-oxidation of straight-chain fatty acid. Defects in this gene are the cause of long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycemia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:210187939-210225491
Strand Reverse strand
Band q34
Transcripts
ENST00000233710 ENSP00000233710
ENST00000482502
ENST00000498120
ENST00000482523
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000062 fatty-acyl-CoA binding
GO:0003995 acyl-CoA dehydrogenase activity
GO:0004466 long-chain-acyl-CoA dehydrogenase activity
GO:0016401 palmitoyl-CoA oxidase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0001659 temperature homeostasis
GO:0006635 fatty acid beta-oxidation
GO:0008152 metabolic process
GO:0019254 carnitine metabolic process, CoA-linked
GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0042413 carnitine catabolic process
GO:0042758 long-chain fatty acid catabolic process
GO:0044242 cellular lipid catabolic process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045717 negative regulation of fatty acid biosynthetic process
GO:0046322 negative regulation of fatty acid oxidation
GO:0051289 protein homotetramerization
GO:0055114 oxidation-reduction process
GO:0090181 regulation of cholesterol metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0031966 mitochondrial membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026003
View Gene Order
ENSBTAG00000010579
Not yet available
Pathways
NETPATH
REACTOME
REACT_2108
Beta oxidation of myristoyl-CoA to lauroyl-CoA pathway
REACT_735
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_1473
Mitochondrial Fatty Acid Beta-Oxidation pathway
REACT_1541
mitochondrial fatty acid beta-oxidation of saturated fatty acids pathway
REACT_111217
Metabolism pathway
KEGG
hsa00071
Fatty acid degradation pathway
hsa03320
PPAR signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt P28330
TrEMBL B4DJN8
UniProt Splice Variant
Entrez Gene 33
UniGene Hs.471277
RefSeq NM_001608
HUGO HGNC:88
OMIM 609576
CCDS CCDS2389
HPRD 01939
IMGT
EMBL AC006994 AK296161 AK313498 BC039063 BC064549 CH471063 M74096
GenPept AAA51565 AAH39063 AAH64549 AAY14881 BAG36280 BAG58900 EAW70481
RNA Seq Atlas 33

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca