Homo sapiens Gene: SFTPD
Summary
InnateDB Gene IDBG-80187.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SFTPD
Gene Name surfactant protein D
Synonyms COLEC7; PSP-D; SFTP4; SP-D;
Species Homo sapiens
Ensembl Gene ENSG00000133661
Encoded Proteins
surfactant protein D
surfactant protein D
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
SFTPD inhibits lipopolysaccharide (LPS)-induced inflammatory cell responses by altering LPS binding to its receptors where it binds to a complex of TLR4/LY96 (MD-2) with high affinity and significantly reduces LY96 binding to both serotypes of LPS.
SFTPD, upon S-nitrosylation, controls inflammatory function by acting as a chemoattractant for macrophages and inducing p38 MAPK phosphorylation.
SFTPD is a carbohydrate pattern recognition molecule of innate immunity that significantly enhances phagocytosis and killing of Aspergillus fumigatus, a pathogenic fungus, by neutrophils and macrophages.
SFTPD can attenuate bacterial and viral infection and inflammation by acting as an opsonin and by regulating innate immune cell functions.
SFTPD binds to Mycobacterium avium lipoarabinomannan and resulting in the agglutination of the pathogen. The presence of SFTPD promotes the phagocytosis of M. avium by macrophages.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Sftpd binds to Mycobacterium avium lipoarabinomannan and resulting in the agglutination of the pathogen. The presence of Sftpd promotes the phagocytosis of M. avium by macrophages. (Demonstrated in human)
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 10:79937740-79982614
Strand Reverse strand
Band q22.3
Transcripts
ENST00000372292 ENSP00000361366
ENST00000444384 ENSP00000394325
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030246 carbohydrate binding
Biological Process
GO:0001817 regulation of cytokine production
GO:0006898 receptor-mediated endocytosis
GO:0007585 respiratory gaseous exchange
GO:0042130 negative regulation of T cell proliferation
GO:0042742 defense response to bacterium
GO:0043129 surfactant homeostasis
GO:0045085 negative regulation of interleukin-2 biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0048246 macrophage chemotaxis
GO:0048286 lung alveolus development
GO:0050766 positive regulation of phagocytosis
GO:0072593 reactive oxygen species metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005581 collagen trimer
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0030139 endocytic vesicle
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Toll Like Receptor TLR1:TLR2 Cascade pathway
Cell-Cell communication pathway
Innate Immune System pathway
Signal regulatory protein (SIRP) family interactions pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Immune System pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
Phagosome pathway
INOH
PID BIOCARTA
PID NCI
Regulation of retinoblastoma protein
FOXA1 transcription factor network
Cross-References
SwissProt P35247
TrEMBL Q5T0M2
UniProt Splice Variant
Entrez Gene 6441
UniGene Hs.253495
RefSeq NM_003019
HUGO HGNC:10803
OMIM 178635
CCDS CCDS7362
HPRD
IMGT
EMBL AL512662 AY216721 BC022318 CR541948 L05483 L05484 L05485 X65018
GenPept AAB59450 AAH22318 AAO22991 CAA46152 CAG46746 CAI14436
RNA Seq Atlas 6441