InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SFTPD

Summary

InnateDB Gene

IDBG-80187.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SFTPD

Gene Name

surfactant protein D

Synonyms

COLEC7; PSP-D; SFTP4; SP-D

Species

Homo sapiens

Ensembl Gene

ENSG00000133661

Encoded Proteins

IDBP-80189

surfactant protein D

IDBP-381249

surfactant protein D

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 18990700

SFTPD inhibits lipopolysaccharide (LPS)-induced inflammatory cell responses by altering LPS binding to its receptors where it binds to a complex of TLR4/LY96 (MD-2) with high affinity and significantly reduces LY96 binding to both serotypes of LPS.

PMID 19007302

SFTPD, upon S-nitrosylation, controls inflammatory function by acting as a chemoattractant for macrophages and inducing p38 MAPK phosphorylation.

PMID 20413160

SFTPD is a carbohydrate pattern recognition molecule of innate immunity that significantly enhances phagocytosis and killing of Aspergillus fumigatus, a pathogenic fungus, by neutrophils and macrophages.

PMID 20418258

SFTPD can attenuate bacterial and viral infection and inflammation by acting as an opsonin and by regulating innate immune cell functions.

PMID 21821801

SFTPD binds to Mycobacterium avium lipoarabinomannan and resulting in the agglutination of the pathogen. The presence of SFTPD promotes the phagocytosis of M. avium by macrophages.

InnateDB Annotation from Orthologs

Summary

PMID 21821801

[Mus musculus] Sftpd binds to Mycobacterium avium lipoarabinomannan and resulting in the agglutination of the pathogen. The presence of Sftpd promotes the phagocytosis of M. avium by macrophages. (Demonstrated in human)

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:79937740-79982614

Strand

Reverse strand

Band

q22.3

Transcripts

ENST00000372292	ENSP00000361366
ENST00000444384	ENSP00000394325

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030246	carbohydrate binding

Biological Process

GO:0001817	regulation of cytokine production
GO:0006898	receptor-mediated endocytosis
GO:0007585	respiratory gaseous exchange
GO:0042130	negative regulation of T cell proliferation
GO:0042742	defense response to bacterium
GO:0043129	surfactant homeostasis
GO:0045085	negative regulation of interleukin-2 biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0048246	macrophage chemotaxis
GO:0048286	lung alveolus development
GO:0050766	positive regulation of phagocytosis
GO:0072593	reactive oxygen species metabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005581	collagen trimer
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0030139	endocytic vesicle