InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SFTPD

Summary

InnateDB Protein

IDBP-80189.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SFTPD

Protein Name

surfactant protein D

Synonyms

COLEC7; PSP-D; SFTP4; SP-D;

Species

Homo sapiens

Ensembl Protein

ENSP00000361366

InnateDB Gene

IDBG-80187 (SFTPD)

Protein Structure

UniProt Annotation

Function

Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties. {ECO:0000269PubMed:23478426}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.

Disease Associations

Tissue Specificity

Expressed in lung, brain, pancreas and adipose tissue (mainly mature adipocytes). {ECO:0000269PubMed:23478426}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030246	carbohydrate binding

Biological Process

GO:0001817	regulation of cytokine production
GO:0006898	receptor-mediated endocytosis
GO:0007585	respiratory gaseous exchange
GO:0042130	negative regulation of T cell proliferation
GO:0042742	defense response to bacterium
GO:0043129	surfactant homeostasis
GO:0045085	negative regulation of interleukin-2 biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0048246	macrophage chemotaxis
GO:0048286	lung alveolus development
GO:0050766	positive regulation of phagocytosis
GO:0072593	reactive oxygen species metabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005581	collagen trimer
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0030139	endocytic vesicle

Protein Structure and Domains

PDB ID

InterPro

IPR001304 C-type lectin
IPR008160 Collagen triple helix repeat
IPR015097 Lung surfactant protein D coiled-coil trimerisation
IPR016187 C-type lectin fold

PFAM

PF00059
PF01391
PF09006

PRINTS

PIRSF

SMART

SM00034

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P35247