Homo sapiens Gene: PTPN3
Summary
InnateDB Gene IDBG-80258.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPN3
Gene Name protein tyrosine phosphatase, non-receptor type 3
Synonyms PTP-H1; PTPH1;
Species Homo sapiens
Ensembl Gene ENSG00000070159
Encoded Proteins
protein tyrosine phosphatase, non-receptor type 3
protein tyrosine phosphatase, non-receptor type 3
protein tyrosine phosphatase, non-receptor type 3
protein tyrosine phosphatase, non-receptor type 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:109375466-109498313
Strand Reverse strand
Band q31.3
Transcripts
ENST00000374541 ENSP00000363667
ENST00000262539 ENSP00000262539
ENST00000446349 ENSP00000395384
ENST00000412145 ENSP00000416654
ENST00000497739
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001784 phosphotyrosine binding
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016791 phosphatase activity
GO:0051117 ATPase binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0045930 negative regulation of mitotic cell cycle
GO:0051045 negative regulation of membrane protein ectodomain proteolysis
GO:0097421 liver regeneration
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0009898 cytoplasmic side of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TCR pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.436429
RefSeq NM_001145368 NM_001145369 NM_001145370 NM_001145371 NM_001145372 NM_002829 XM_006717197 XM_006717198 XM_006717199 XM_006717200 XM_006717201 XM_006717202 XM_006717203 XM_006717204 XM_006717205 XM_006717206 XM_006717207
HUGO
OMIM
CCDS CCDS48000 CCDS48001 CCDS6776
HPRD 06767
IMGT
EMBL
GenPept
RNA Seq Atlas