Homo sapiens Gene: PTPN3 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-80258.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | PTPN3 | ||||||||||||||||||
Gene Name | protein tyrosine phosphatase, non-receptor type 3 | ||||||||||||||||||
Synonyms | PTP-H1; PTPH1 | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000070159 | ||||||||||||||||||
Encoded Proteins |
protein tyrosine phosphatase, non-receptor type 3
protein tyrosine phosphatase, non-receptor type 3
protein tyrosine phosphatase, non-receptor type 3
protein tyrosine phosphatase, non-receptor type 3
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 9:109375466-109498313 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | q31.3 | ||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||
NETPATH |
TCR pathway
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REACTOME | |||||||||||||||||||
KEGG | |||||||||||||||||||
INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | |||||||||||||||||||
UniGene | Hs.436429 | ||||||||||||||||||
RefSeq | NM_001145368 NM_001145369 NM_001145370 NM_001145371 NM_001145372 NM_002829 XM_006717197 XM_006717198 XM_006717199 XM_006717200 XM_006717201 XM_006717202 XM_006717203 XM_006717204 XM_006717205 XM_006717206 XM_006717207 | ||||||||||||||||||
HUGO | |||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS48000 CCDS48001 CCDS6776 | ||||||||||||||||||
HPRD | 06767 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | |||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||