Homo sapiens Gene: BEX2
Summary
InnateDB Gene IDBG-80482.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BEX2
Gene Name brain expressed X-linked 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000133134
Encoded Proteins
brain expressed X-linked 2
brain expressed X-linked 2
brain expressed X-linked 2
brain expressed X-linked 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the brain expressed X-linked gene family. The encoded protein interacts with the transcription factor LIM domain only 2 in a DNA-binding complex that recognizes the E-box element and promotes transcription. This gene has been found to be a tumor suppressor that is silenced in human glioma. In breast cancer cells, this gene product modulates apoptosis in response to estrogen and tamoxifen, and enhances the anti-proliferative effect of tamoxifen. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:103309346-103311046
Strand Reverse strand
Band q22.2
Transcripts
ENST00000372677 ENSP00000361762
ENST00000372674 ENSP00000361759
ENST00000449185 ENSP00000394915
ENST00000536889 ENSP00000442521
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006915 apoptotic process
GO:0007049 cell cycle
GO:0042981 regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q9BXY8
TrEMBL X6RDN0
UniProt Splice Variant
Entrez Gene 84707
UniGene
RefSeq NM_001168399 NM_001168400 NM_001168401 NM_032621
HUGO HGNC:30933
OMIM 300691
CCDS CCDS14505 CCDS55467
HPRD
IMGT
EMBL AF251053 AK312085 AL133348 AY833560 BC015522 CH471190 Z70233
GenPept AAH15522 AAK34943 AAX40678 BAG35021 CAD24039 CAI43071 CAI43072 EAW54715 EAW54716
RNA Seq Atlas 84707