Version 5.4
Homo sapiens Protein: BEX2
Summary
InnateDB Protein IDBP-80486.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BEX2
Protein Name brain expressed X-linked 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000361759
InnateDB Gene IDBG-80482 (BEX2)
Protein Structure
UniProt Annotation
Function Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer. Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members BAD, BAK1 and PUMA. Required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of CCND1 and CDKN1A. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity. {ECO:0000269PubMed:19711341}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269PubMed:16314316}.
Disease Associations
Tissue Specificity Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. Widely expressed in breast cancer cell lines. {ECO:0000269PubMed:15958283, ECO:0000269PubMed:19711341}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006915 apoptotic process
GO:0007049 cell cycle
GO:0042981 regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR007623 Brain-expressed X-linked protein
IPR021156 Transcription elongation factor A-like/Brain expressed X-linked-like
PFAM PF04538
PRINTS
PIRSF PIRSF008633
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BXY8
PhosphoSite PhosphoSite-Q9BXY8
TrEMBL X6RDN0
UniProt Splice Variant
Entrez Gene 84707
UniGene
RefSeq NP_001161873
HUGO HGNC:30933
OMIM 300691
CCDS CCDS14505
HPRD 06484
IMGT
EMBL AF251053 AK312085 AL133348 AY833560 BC015522 CH471190 Z70233
GenPept AAH15522 AAK34943 AAX40678 BAG35021 CAD24039 CAI43071 CAI43072 EAW54715 EAW54716

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca