Homo sapiens Gene: PTGIS
Summary
InnateDB Gene IDBG-80513.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTGIS
Gene Name prostaglandin I2 (prostacyclin) synthase
Synonyms CYP8; CYP8A1; PGIS; PTGI;
Species Homo sapiens
Ensembl Gene ENSG00000124212
Encoded Proteins
prostaglandin I2 (prostacyclin) synthase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:49503874-49568146
Strand Reverse strand
Band q13.13
Transcripts
ENST00000244043 ENSP00000244043
ENST00000478971
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0008116 prostaglandin-I synthase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
Biological Process
GO:0001516 prostaglandin biosynthetic process
GO:0006690 icosanoid metabolic process
GO:0006805 xenobiotic metabolic process
GO:0019369 arachidonic acid metabolic process
GO:0019371 cyclooxygenase pathway
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:0044281 small molecule metabolic process
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0045766 positive regulation of angiogenesis
GO:0050728 negative regulation of inflammatory response
GO:0055114 oxidation-reduction process
GO:0071347 cellular response to interleukin-1
GO:0071354 cellular response to interleukin-6
GO:0071456 cellular response to hypoxia
GO:0097190 apoptotic signaling pathway
GO:1900119 positive regulation of execution phase of apoptosis
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005901 caveola
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Sterols are 12-hydroxylated by CYP8B1 pathway
Metabolism of lipids and lipoproteins pathway
Arachidonic acid metabolism pathway
Defective HLCS causes multiple carboxylase deficiency pathway
Defective MUT causes methylmalonic aciduria mut type pathway
Defective MMAA causes methylmalonic aciduria type cblA pathway
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) pathway
Defective TCN2 causes hereditary megaloblastic anemia pathway
Synthesis of bile acids and bile salts via 27-hydroxycholesterol pathway
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway
Bile acid and bile salt metabolism pathway
Metabolism of water-soluble vitamins and cofactors pathway
Synthesis of bile acids and bile salts via 24-hydroxycholesterol pathway
Defective AMN causes hereditary megaloblastic anemia 1 pathway
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG pathway
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF pathway
Nicotinamide salvaging pathway
Defective CD320 causes methylmalonic aciduria pathway
Defects in cobalamin (B12) metabolism pathway
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC pathway
Nicotinate metabolism pathway
Defects in biotin (Btn) metabolism pathway
Cytochrome P450 - arranged by substrate type pathway
Defective BTD causes biotidinase deficiency pathway
Endogenous sterols pathway
Defective GIF causes intrinsic factor deficiency pathway
Defects in vitamin and cofactor metabolism pathway
Defective CUBN causes hereditary megaloblastic anemia 1 pathway
Synthesis of bile acids and bile salts pathway
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD pathway
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE pathway
Metabolism pathway
Defective MMAB causes methylmalonic aciduria type cblB pathway
Biological oxidations pathway
Eicosanoids pathway
Disease pathway
Phase 1 - Functionalization of compounds pathway
Metabolism of vitamins and cofactors pathway
KEGG
Arachidonic acid metabolism pathway
INOH
Prostaglandin Leukotriene metabolism pathway
PID BIOCARTA
Eicosanoid metabolism [Biocarta view]
PID NCI
Cross-References
SwissProt Q16647
TrEMBL Q6LEN0
UniProt Splice Variant
Entrez Gene 5740
UniGene Hs.302085
RefSeq NM_000961
HUGO HGNC:9603
OMIM 601699
CCDS CCDS13419
HPRD 09046
IMGT
EMBL AF297048 AF297049 AF297050 AF297051 AF297052 AL118525 BC101809 BC101811 D38145 D84124
GenPept AAG31781 AAG31782 AAG31783 AAG31784 AAG31785 AAI01810 AAI01812 BAA07343 BAA28219 CAC14162
RNA Seq Atlas 5740