InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTGIS

Summary

InnateDB Protein

IDBP-80515.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTGIS

Protein Name

prostaglandin I2 (prostacyclin) synthase

Synonyms

CYP8; CYP8A1; PGIS; PTGI;

Species

Homo sapiens

Ensembl Protein

ENSP00000244043

InnateDB Gene

IDBG-80513 (PTGIS)

Protein Structure

UniProt Annotation

Function

Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass membrane protein.

Disease Associations

Tissue Specificity

Widely expressed; particularly abundant in ovary, heart, skeletal muscle, lung and prostate.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0008116	prostaglandin-I synthase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding

Biological Process

GO:0001516	prostaglandin biosynthetic process
GO:0006690	icosanoid metabolic process
GO:0006805	xenobiotic metabolic process
GO:0019369	arachidonic acid metabolic process
GO:0019371	cyclooxygenase pathway
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:0044281	small molecule metabolic process
GO:0045019	negative regulation of nitric oxide biosynthetic process
GO:0045766	positive regulation of angiogenesis
GO:0050728	negative regulation of inflammatory response
GO:0055114	oxidation-reduction process
GO:0071347	cellular response to interleukin-1
GO:0071354	cellular response to interleukin-6
GO:0071456	cellular response to hypoxia
GO:0097190	apoptotic signaling pathway
GO:1900119	positive regulation of execution phase of apoptosis

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005901	caveola
GO:0016021	integral component of membrane