InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HLA-DRA

Summary

InnateDB Gene

IDBG-80796.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HLA-DRA

Gene Name

major histocompatibility complex, class II, DR alpha

Synonyms

HLA-DRA1; MLRW

Species

Homo sapiens

Ensembl Gene

ENSG00000204287

Encoded Proteins

IDBP-80800

major histocompatibility complex, class II, DR alpha

IDBP-239683

major histocompatibility complex, class II, DR alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:32439842-32445046

Strand

Forward strand

Band

p21.32

Transcripts

ENST00000374982	ENSP00000364121
ENST00000395388	ENSP00000378786

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.

Experimentally validated
Total	29 [view]
Protein-Protein	26 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0023026	MHC class II protein complex binding
GO:0032395	MHC class II receptor activity
GO:0042605	peptide antigen binding

Biological Process

GO:0002503	peptide antigen assembly with MHC class II protein complex
GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0002506	polysaccharide assembly with MHC class II protein complex
GO:0006955	immune response
GO:0019221	cytokine-mediated signaling pathway
GO:0019882	antigen processing and presentation
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0031295	T cell costimulation
GO:0050852	T cell receptor signaling pathway
GO:0050890	cognition
GO:0060333	interferon-gamma-mediated signaling pathway

Cellular Component

GO:0000139	Golgi membrane
GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0012507	ER to Golgi transport vesicle membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030658	transport vesicle membrane
GO:0030666	endocytic vesicle membrane
GO:0030669	clathrin-coated endocytic vesicle membrane
GO:0031902	late endosome membrane
GO:0032588	trans-Golgi network membrane
GO:0042613	MHC class II protein complex
GO:0070062	extracellular vesicular exosome
GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

REACT_121399

MHC class II antigen presentation pathway

REACT_12555

Downstream TCR signaling pathway

REACT_12623

Generation of second messenger molecules pathway

REACT_12596

Translocation of ZAP-70 to Immunological synapse pathway

REACT_12582

Phosphorylation of CD3 and TCR zeta chains pathway

REACT_25078

Interferon gamma signaling pathway

REACT_19324

PD-1 signaling pathway

REACT_19344

Costimulation by the CD28 family pathway

REACT_12526

TCR signaling pathway

REACT_75790

Cytokine Signaling in Immune system pathway

REACT_25229

Interferon Signaling pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

KEGG

hsa04640

Hematopoietic cell lineage pathway

hsa04514

Cell adhesion molecules (CAMs) pathway

hsa04612

Antigen processing and presentation pathway

hsa04940

Type I diabetes mellitus pathway

hsa05330

Allograft rejection pathway

hsa05320

Autoimmune thyroid disease pathway

hsa05322

Systemic lupus erythematosus pathway

hsa05332

Graft-versus-host disease pathway

hsa05310

Asthma pathway

hsa04672

Intestinal immune network for IgA production pathway

hsa05416

Viral myocarditis pathway

hsa05140

Leishmaniasis pathway

hsa05150

Staphylococcus aureus infection pathway

hsa05145

Toxoplasmosis pathway

hsa04145

Phagosome pathway

INOH

INOH website

CD4 T cell receptor signaling pathway

PID NCI

cxcr4_pathway

CXCR4-mediated signaling events

tcr_pathway

TCR signaling in na�ve CD4+ T cells

il12_2pathway

IL12-mediated signaling events

il12_stat4pathway

IL12 signaling mediated by STAT4

Cross-References

SwissProt

P01903

TrEMBL

A1A436 O19670 O19720 Q29868

UniProt Splice Variant

Entrez Gene

3122

UniGene

RefSeq

NM_019111

HUGO

HGNC:4947

OMIM

142860

CCDS

CCDS4750

HPRD

00833

IMGT

EMBL

AF481359 AL662796 AL670296 AL935032 AY669056 BC032350 BC071659 BX120007 CH471081 CR457013 J00194 J00201 J00203 J00204 K01171 M35979 M60334 V00523 V00524 V00528 X00274 Z84814

GenPept

AAA36275 AAA36283 AAA36301 AAA36302 AAA59783 AAA59785 AAH32350 AAH71659 AAO23887 AAV74560 CAA23782 CAA23783 CAA23787 CAA25076 CAB06609 CAG33294 CAI17571 CAI18266 CAI18476 CAM26203 EAX03630

RNA Seq Atlas

3122