Homo sapiens Gene: HLA-DRA
Summary
InnateDB Gene IDBG-80796.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HLA-DRA
Gene Name major histocompatibility complex, class II, DR alpha
Synonyms HLA-DRA1; MLRW;
Species Homo sapiens
Ensembl Gene ENSG00000204287
Encoded Proteins
major histocompatibility complex, class II, DR alpha
major histocompatibility complex, class II, DR alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:32439842-32445046
Strand Forward strand
Band p21.32
Transcripts
ENST00000374982 ENSP00000364121
ENST00000395388 ENSP00000378786
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
Experimentally validated
Total 29 [view]
Protein-Protein 26 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0023026 MHC class II protein complex binding
GO:0032395 MHC class II receptor activity
GO:0042605 peptide antigen binding
Biological Process
GO:0002503 peptide antigen assembly with MHC class II protein complex
GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0002506 polysaccharide assembly with MHC class II protein complex
GO:0006955 immune response
GO:0019221 cytokine-mediated signaling pathway
GO:0019882 antigen processing and presentation
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0031295 T cell costimulation
GO:0050852 T cell receptor signaling pathway
GO:0050890 cognition
GO:0060333 interferon-gamma-mediated signaling pathway
Cellular Component
GO:0000139 Golgi membrane
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030658 transport vesicle membrane
GO:0030666 endocytic vesicle membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0031902 late endosome membrane
GO:0032588 trans-Golgi network membrane
GO:0042613 MHC class II protein complex
GO:0070062 extracellular vesicular exosome
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
PD-1 signaling pathway
MHC class II antigen presentation pathway
TCR signaling pathway
Cytokine Signaling in Immune system pathway
Interferon Signaling pathway
Adaptive Immune System pathway
Immune System pathway
Downstream TCR signaling pathway
Interferon gamma signaling pathway
Phosphorylation of CD3 and TCR zeta chains pathway
Generation of second messenger molecules pathway
Costimulation by the CD28 family pathway
Translocation of ZAP-70 to Immunological synapse pathway
KEGG
Phagosome pathway
Cell adhesion molecules (CAMs) pathway
Antigen processing and presentation pathway
Hematopoietic cell lineage pathway
Intestinal immune network for IgA production pathway
Type I diabetes mellitus pathway
Leishmaniasis pathway
Toxoplasmosis pathway
Staphylococcus aureus infection pathway
Asthma pathway
Autoimmune thyroid disease pathway
Systemic lupus erythematosus pathway
Allograft rejection pathway
Graft-versus-host disease pathway
Viral myocarditis pathway
INOH
CD4 T cell receptor signaling pathway
PID BIOCARTA
The co-stimulatory signal during t-cell activation [Biocarta view]
Il 4 signaling pathway [Biocarta view]
Role of mef2d in t-cell apoptosis [Biocarta view]
Lck and fyn tyrosine kinases in initiation of tcr activation [Biocarta view]
Antigen processing and presentation [Biocarta view]
T cell receptor signaling pathway [Biocarta view]
Activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor [Biocarta view]
PID NCI
CXCR4-mediated signaling events
TCR signaling in na´ve CD4+ T cells
IL12-mediated signaling events
IL12 signaling mediated by STAT4
Cross-References
SwissProt P01903
TrEMBL A1A436 O19670 O19720 Q29868 Q30118
UniProt Splice Variant
Entrez Gene 3122
UniGene
RefSeq NM_019111
HUGO HGNC:4947
OMIM 142860
CCDS CCDS4750
HPRD
IMGT
EMBL AF481359 AL662796 AL670296 AL935032 AY669056 BC032350 BC071659 BX120007 CH471081 CR457013 J00194 J00201 J00203 J00204 K01171 M35979 M60333 M60334 V00523 V00524 V00528 X00274 Z84814
GenPept AAA36275 AAA36283 AAA36301 AAA36302 AAA59783 AAA59785 AAA59787 AAH32350 AAH71659 AAO23887 AAV74560 CAA23782 CAA23783 CAA23787 CAA25076 CAB06609 CAG33294 CAI17571 CAI18266 CAI18476 CAM26203 EAX03630
RNA Seq Atlas 3122