Homo sapiens Gene: HLA-DQA1
Summary
InnateDB Gene IDBG-81099.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HLA-DQA1
Gene Name major histocompatibility complex, class II, DQ alpha 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000196735
Encoded Proteins
major histocompatibility complex, class II, DQ alpha 1
major histocompatibility complex, class II, DQ alpha 1
major histocompatibility complex, class II, DQ alpha 1
major histocompatibility complex, class II, DQ alpha 1
major histocompatibility complex, class II, DQ alpha 1
major histocompatibility complex, class II, DQ alpha 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] H2-Aa is an intracellular MHC class II molecule that can act as an adaptor to promote the full activation of the TLR-triggered innate immune response.
Entrez Gene
Summary HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:32628179-32647062
Strand Forward strand
Band p21.32
Transcripts
ENST00000343139 ENSP00000339398
ENST00000374949 ENSP00000364087
ENST00000395363 ENSP00000378767
ENST00000422863 ENSP00000405797
ENST00000496318 ENSP00000437302
ENST00000482745 ENSP00000436546
ENST00000460633
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0032395 MHC class II receptor activity
GO:0042605 peptide antigen binding
Biological Process
GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0006955 immune response
GO:0019221 cytokine-mediated signaling pathway
GO:0019882 antigen processing and presentation
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0031295 T cell costimulation
GO:0050852 T cell receptor signaling pathway
GO:0060333 interferon-gamma-mediated signaling pathway
Cellular Component
GO:0000139 Golgi membrane
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0010008 endosome membrane
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030658 transport vesicle membrane
GO:0030666 endocytic vesicle membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0032588 trans-Golgi network membrane
GO:0042613 MHC class II protein complex
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
PD-1 signaling pathway
MHC class II antigen presentation pathway
TCR signaling pathway
Cytokine Signaling in Immune system pathway
Interferon Signaling pathway
Adaptive Immune System pathway
Immune System pathway
Downstream TCR signaling pathway
Interferon gamma signaling pathway
Phosphorylation of CD3 and TCR zeta chains pathway
Generation of second messenger molecules pathway
Costimulation by the CD28 family pathway
Translocation of ZAP-70 to Immunological synapse pathway
KEGG
Phagosome pathway
Cell adhesion molecules (CAMs) pathway
Antigen processing and presentation pathway
Intestinal immune network for IgA production pathway
Type I diabetes mellitus pathway
Leishmaniasis pathway
Toxoplasmosis pathway
Staphylococcus aureus infection pathway
Asthma pathway
Autoimmune thyroid disease pathway
Systemic lupus erythematosus pathway
Allograft rejection pathway
Graft-versus-host disease pathway
Viral myocarditis pathway
INOH
CD4 T cell receptor signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.387679 Hs.625753 Hs.666607 Hs.676554 Hs.706240
RefSeq NM_002122 XM_006715079
HUGO
OMIM
CCDS CCDS4752
HPRD 06765
IMGT
EMBL
GenPept
RNA Seq Atlas