Mus musculus Gene: H2-Aa
Summary
InnateDB Gene IDBG-170982.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol H2-Aa
Gene Name histocompatibility 2, class II antigen A, alpha
Synonyms Aalpha; H-2Aa; H2Aa; I-Aalpha; Ia-1; Ia1; IAalpha;
Species Mus musculus
Ensembl Gene ENSMUSG00000036594
Encoded Proteins
histocompatibility 2, class II antigen A, alpha
histocompatibility 2, class II antigen A, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
H2-Aa is an intracellular MHC class II molecule that can act as an adaptor to promote the full activation of the TLR-triggered innate immune response.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196735:
HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:34282744-34287827
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000040655 ENSMUSP00000046105
ENSMUST00000174751 ENSMUSP00000133399
ENSMUST00000165139
ENSMUST00000173944
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042605 peptide antigen binding
Biological Process
GO:0006955 immune response
GO:0019882 antigen processing and presentation
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0034341 response to interferon-gamma
GO:0045087 innate immune response (InnateDB)
GO:0045582 positive regulation of T cell differentiation
GO:0048002 antigen processing and presentation of peptide antigen
Cellular Component
GO:0005764 lysosome
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042613 MHC class II protein complex
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
PD-1 signaling pathway
Phosphorylation of CD3 and TCR zeta chains pathway
Downstream TCR signaling pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
MHC class II antigen presentation pathway
Translocation of ZAP-70 to Immunological synapse pathway
Costimulation by the CD28 family pathway
Interferon gamma signaling pathway
Interferon Signaling pathway
Adaptive Immune System pathway
Generation of second messenger molecules pathway
TCR signaling pathway
KEGG
Phagosome pathway
Cell adhesion molecules (CAMs) pathway
Antigen processing and presentation pathway
Intestinal immune network for IgA production pathway
Type I diabetes mellitus pathway
Leishmaniasis pathway
Toxoplasmosis pathway
Staphylococcus aureus infection pathway
Asthma pathway
Autoimmune thyroid disease pathway
Systemic lupus erythematosus pathway
Allograft rejection pathway
Graft-versus-host disease pathway
Viral myocarditis pathway
INOH
CD4 T cell receptor signaling pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
PD-1 signaling pathway
MHC class II antigen presentation pathway
TCR signaling pathway
Cytokine Signaling in Immune system pathway
Interferon Signaling pathway
Adaptive Immune System pathway
Immune System pathway
Downstream TCR signaling pathway
Interferon gamma signaling pathway
Phosphorylation of CD3 and TCR zeta chains pathway
Generation of second messenger molecules pathway
Costimulation by the CD28 family pathway
Translocation of ZAP-70 to Immunological synapse pathway
KEGG
Phagosome pathway
Cell adhesion molecules (CAMs) pathway
Antigen processing and presentation pathway
Intestinal immune network for IgA production pathway
Type I diabetes mellitus pathway
Leishmaniasis pathway
Toxoplasmosis pathway
Staphylococcus aureus infection pathway
Asthma pathway
Autoimmune thyroid disease pathway
Systemic lupus erythematosus pathway
Allograft rejection pathway
Graft-versus-host disease pathway
Viral myocarditis pathway
INOH
CD4 T cell receptor signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_010378
OMIM
CCDS CCDS28645
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas