InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CYP24A1

Summary

InnateDB Gene

IDBG-81619.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP24A1

Gene Name

cytochrome P450, family 24, subfamily A, polypeptide 1

Synonyms

CP24; CYP24; HCAI; P450-CC24

Species

Homo sapiens

Ensembl Gene

ENSG00000019186

Encoded Proteins

IDBP-81621

cytochrome P450, family 24, subfamily A, polypeptide 1

IDBP-238505

cytochrome P450, family 24, subfamily A, polypeptide 1

IDBP-238507

cytochrome P450, family 24, subfamily A, polypeptide 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:54153449-54173973

Strand

Reverse strand

Band

q13.2

Transcripts

ENST00000216862	ENSP00000216862
ENST00000395955	ENSP00000379285
ENST00000395954	ENSP00000379284
ENST00000460643
ENST00000487593
ENST00000472970

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0008403	25-hydroxycholecalciferol-24-hydroxylase activity
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0030342	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity

Biological Process

GO:0001649	osteoblast differentiation
GO:0006766	vitamin metabolic process
GO:0006805	xenobiotic metabolic process
GO:0008202	steroid metabolic process
GO:0033280	response to vitamin D
GO:0042359	vitamin D metabolic process
GO:0042369	vitamin D catabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0070561	vitamin D receptor signaling pathway

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000038567

View Gene Order

ENSBTAG00000002765

Not yet available

Pathways

NETPATH

REACTOME

REACT_13523

Vitamin D (calciferol) metabolism pathway

REACT_13450

Vitamins pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_11057

Metabolism of steroid hormones and vitamin D pathway

REACT_13567

Cytochrome P450 - arranged by substrate type pathway

REACT_111217

Metabolism pathway

REACT_13433

Biological oxidations pathway

REACT_13705

Phase 1 - Functionalization of compounds pathway

KEGG

hsa00100

Steroid biosynthesis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.596674 Hs.607492 Hs.89663

RefSeq

NM_000782 NM_001128915 XM_005260304

HUGO

OMIM

CCDS

CCDS33491 CCDS46616

HPRD

00522

IMGT

EMBL

GenPept

RNA Seq Atlas