Homo sapiens Gene: DOK5
Summary
InnateDB Gene IDBG-81690.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DOK5
Gene Name docking protein 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000101134
Encoded Proteins
docking protein 5
docking protein 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. In contrast to other DOK family proteins, this protein does not interact with RASGAP. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:54475597-54651171
Strand Forward strand
Band q13.2
Transcripts
ENST00000262593 ENSP00000262593
ENST00000395939 ENSP00000379270
ENST00000491469
ENST00000484860
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005057 receptor signaling protein activity
GO:0005158 insulin receptor binding
Biological Process
GO:0000165 MAPK cascade
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007399 nervous system development
Cellular Component
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Signaling events regulated by Ret tyrosine kinase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.607042 Hs.656582
RefSeq NM_018431 NM_177959 XM_005260451
HUGO
OMIM
CCDS CCDS13446 CCDS13447
HPRD 16317
IMGT
EMBL
GenPept
RNA Seq Atlas