Version 5.4
Homo sapiens Gene: DOK5
Summary
InnateDB Gene IDBG-81690.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DOK5
Gene Name docking protein 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000101134
Encoded Proteins
IDBP-81694
docking protein 5
IDBP-238531
docking protein 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. In contrast to other DOK family proteins, this protein does not interact with RASGAP. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:54475597-54651171
Strand Forward strand
Band q13.2
Transcripts
ENST00000262593 ENSP00000262593
ENST00000395939 ENSP00000379270
ENST00000491469
ENST00000484860
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005057 receptor signaling protein activity
GO:0005158 insulin receptor binding
Biological Process
GO:0000165 MAPK cascade
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007399 nervous system development
Cellular Component
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000027560
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
ret_pathway
Signaling events regulated by Ret tyrosine kinase
Cross-References
SwissProt Q9P104
TrEMBL
UniProt Splice Variant
Entrez Gene 55816
UniGene Hs.607042 Hs.656582
RefSeq NM_177959 XM_005260451 NM_018431
HUGO HGNC:16173
OMIM 608334
CCDS CCDS13447 CCDS13446
HPRD 16317
IMGT
EMBL AF132732 AF466368 AL050069 AL118501 AL162292 BC008992
GenPept AAF66443 AAH08992 AAL74194 CAB43255 CAI16465 CAI19415 CAI19416
RNA Seq Atlas 55816

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca