Version 5.4
Homo sapiens Gene: MID2
Summary
InnateDB Gene IDBG-81697.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MID2
Gene Name midline 2
Synonyms FXY2; MRX101; RNF60; TRIM1
Species Homo sapiens
Ensembl Gene ENSG00000080561
Encoded Proteins
IDBP-81701
midline 2
IDBP-378853
midline 2
IDBP-378870
midline 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 23438823
MID2 was identified in a systematic screen for positive regulators of innate immune responses.
Entrez Gene
Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures in the cytoplasm. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:107825755-107927193
Strand Forward strand
Band q22.3
Transcripts
ENST00000262843 ENSP00000262843
ENST00000451923 ENSP00000410730
ENST00000443968 ENSP00000413976
ENST00000474517
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 39 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0051219 phosphoprotein binding
Biological Process
GO:0016567 protein ubiquitination
GO:0032897 negative regulation of viral transcription
GO:0035372 protein localization to microtubule
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
GO:0046597 negative regulation of viral entry into host cell
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:1902187 negative regulation of viral release from host cell
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000000266
View Gene Order
Cross-References
SwissProt
TrEMBL A6PVI4
UniProt Splice Variant
Entrez Gene 11043
UniGene Hs.12256
RefSeq NM_012216 NM_052817
HUGO HGNC:7096
OMIM 300204
CCDS CCDS14532 CCDS14533
HPRD 02191
IMGT
EMBL AL034399 AL109946
GenPept
RNA Seq Atlas 11043

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca