Homo sapiens Gene: MID2
Summary
InnateDB Gene IDBG-81697.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MID2
Gene Name midline 2
Synonyms FXY2; MRX101; RNF60; TRIM1;
Species Homo sapiens
Ensembl Gene ENSG00000080561
Encoded Proteins
midline 2
midline 2
midline 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
MID2 was identified in a systematic screen for positive regulators of innate immune responses.
Entrez Gene
Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures in the cytoplasm. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:107825755-107927193
Strand Forward strand
Band q22.3
Transcripts
ENST00000262843 ENSP00000262843
ENST00000451923 ENSP00000410730
ENST00000443968 ENSP00000413976
ENST00000474517
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 39 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0051219 phosphoprotein binding
Biological Process
GO:0016567 protein ubiquitination
GO:0032897 negative regulation of viral transcription
GO:0035372 protein localization to microtubule
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
GO:0046597 negative regulation of viral entry into host cell
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:1902187 negative regulation of viral release from host cell
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.12256
RefSeq NM_012216 NM_052817
HUGO
OMIM
CCDS CCDS14532 CCDS14533
HPRD 02191
IMGT
EMBL
GenPept
RNA Seq Atlas