Version 5.4
Homo sapiens Gene: SPEG
Summary
InnateDB Gene IDBG-81742.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPEG
Gene Name SPEG complex locus
Synonyms APEG-1; APEG1; BPEG; CNM5; SPEGalpha; SPEGbeta
Species Homo sapiens
Ensembl Gene ENSG00000072195
Encoded Proteins
IDBP-81744
SPEG complex locus
IDBP-236950
SPEG complex locus
IDBP-236954
SPEG complex locus
IDBP-236956
SPEG complex locus
IDBP-236958
SPEG complex locus
IDBP-293001
SPEG complex locus
IDBP-293000
SPEG complex locus
IDBP-389072
SPEG complex locus
IDBP-389073
SPEG complex locus
IDBP-389074
SPEG complex locus
IDBP-389075
SPEG complex locus
IDBP-389076
SPEG complex locus
IDBP-389077
SPEG complex locus
IDBP-809763
SPEG complex locus
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein with similarity to members of the myosin light chain kinase family. This protein family is required for myocyte cytoskeletal development. Studies in mouse have determined that a lack of this protein affected myocardial development. Multiple alternatively spliced transcript variants have been reported for this gene, but the full-length nature of only two variants that encode different protein isoforms has been defined. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:219434846-219498287
Strand Forward strand
Band q35
Transcripts
ENST00000312358 ENSP00000311684
ENST00000396698 ENSP00000379926
ENST00000396689 ENSP00000379920
ENST00000396688 ENSP00000379919
ENST00000396686 ENSP00000379917
ENST00000409595 ENSP00000387344
ENST00000403148 ENSP00000383902
ENST00000435853 ENSP00000393134
ENST00000431523 ENSP00000410986
ENST00000452101 ENSP00000406530
ENST00000420132 ENSP00000397514
ENST00000451076 ENSP00000414549
ENST00000412982 ENSP00000390353
ENST00000498378
ENST00000464989
ENST00000497065
ENST00000491248
ENST00000485813
ENST00000462545
ENST00000463218
ENST00000496786
ENST00000475921
ENST00000485069
ENST00000475104
ENST00000617028 ENSP00000479190
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0001701 in utero embryonic development
GO:0006468 protein phosphorylation
GO:0007517 muscle organ development
GO:0008285 negative regulation of cell proliferation
GO:0042692 muscle cell differentiation
GO:0055013 cardiac muscle cell development
GO:0060541 respiratory system development
GO:0072358 cardiovascular system development
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026207
View Gene Order
ENSBTAG00000046176
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.21639 Hs.734538 Hs.739097
RefSeq NM_001173476 NM_001286811 NM_005876 XM_005246235 XM_005246237 XM_005246238 XM_005246239 XM_005246240 XM_005246241 XM_005246242 XM_006712187 XM_006712188 XM_006712189 XM_006712190 XM_006712191 XM_006712192 XM_006712193 XM_006712194
HUGO
OMIM
CCDS CCDS42824 CCDS54432 CCDS74658
HPRD 10653
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca