Version 5.4
Homo sapiens Gene: POLE3
Summary
InnateDB Gene IDBG-81768.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLE3
Gene Name polymerase (DNA directed), epsilon 3, accessory subunit
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000148229
Encoded Proteins
IDBP-81770
polymerase (DNA directed), epsilon 3 (p17 subunit)
IDBP-81772
polymerase (DNA directed), epsilon 3 (p17 subunit)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:113407235-113410672
Strand Reverse strand
Band q32
Transcripts
ENST00000374171 ENSP00000363286
ENST00000374169 ENSP00000363284
ENST00000479871
ENST00000475080
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 26 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
GO:0043966 histone H3 acetylation
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex
GO:0008622 epsilon DNA polymerase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000028394
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000000252
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
hsa00230
Purine metabolism pathway
hsa00240
Pyrimidine metabolism pathway
hsa03030
DNA replication pathway
hsa03410
Base excision repair pathway
hsa03420
Nucleotide excision repair pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9NRF9
TrEMBL A0A024R829
UniProt Splice Variant
Entrez Gene 54107
UniGene Hs.108112
RefSeq NM_001278255 NM_017443
HUGO HGNC:13546
OMIM 607267
CCDS CCDS6795
HPRD 06274
IMGT
EMBL AF226077 AF261689 AK074629 AK074762 AK074782 AL137066 AY720898 BC003166 BC004170 CH471090 DQ072116
GenPept AAF72417 AAF90133 AAH03166 AAH04170 AAU15052 AAY57326 BAC11099 BAC11190 BAC11206 CAH70100 EAW87381 EAW87382
RNA Seq Atlas 54107

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca