Version 5.4
Homo sapiens Protein: POLE3
Summary
InnateDB Protein IDBP-81770.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLE3
Protein Name polymerase (DNA directed), epsilon 3 (p17 subunit)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000363286
InnateDB Gene IDBG-81768 (POLE3)
Protein Structure
UniProt Annotation
Function Forms a complex with DNA polymerase epsilon subunit CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in all tissues tested, including, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 26 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
GO:0043966 histone H3 acetylation
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex
GO:0008622 epsilon DNA polymerase complex
Protein Structure and Domains
PDB ID
InterPro IPR003958 Transcription factor CBF/NF-Y/archaeal histone
IPR009072 Histone-fold
PFAM PF00808
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NRF9
PhosphoSite PhosphoSite-Q9NRF9
TrEMBL A0A024R829
UniProt Splice Variant
Entrez Gene 54107
UniGene Hs.108112
RefSeq NP_059139
HUGO HGNC:13546
OMIM 607267
CCDS CCDS6795
HPRD 06274
IMGT
EMBL AF226077 AF261689 AK074629 AK074762 AK074782 AL137066 AY720898 BC003166 BC004170 CH471090 DQ072116
GenPept AAF72417 AAF90133 AAH03166 AAH04170 AAU15052 AAY57326 BAC11099 BAC11190 BAC11206 CAH70100 EAW87381 EAW87382

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca