Homo sapiens Gene: ASIC4
Summary
InnateDB Gene IDBG-81849.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASIC4
Gene Name acid-sensing (proton-gated) ion channel family member 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000072182
Encoded Proteins
amiloride-sensitive cation channel 4, pituitary
amiloride-sensitive cation channel 4, pituitary
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:219514170-219538772
Strand Forward strand
Band q35
Transcripts
ENST00000358078 ENSP00000350786
ENST00000347842 ENSP00000326627
ENST00000461395
ENST00000474489
ENST00000473709
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005272 sodium channel activity
GO:0015081 sodium ion transmembrane transporter activity
Biological Process
GO:0006810 transport
GO:0006814 sodium ion transport
GO:0034220 ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Stimuli-sensing channels pathway
Ion channel transport pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q96FT7
TrEMBL
UniProt Splice Variant
Entrez Gene 55515
UniGene
RefSeq NM_182847 XM_005246671
HUGO HGNC:21263
OMIM 606715
CCDS CCDS2442
HPRD 16231
IMGT
EMBL AC009955 AC053503 AC139723 AJ271643 AJ408881 AJ408882 AJ408883 AJ408884 BC010439 BC031812
GenPept AAH10439 AAH31812 AAY15054 CAB93980 CAC51338
RNA Seq Atlas 55515