Version 5.4
Homo sapiens Protein: ASIC4
Summary
InnateDB Protein IDBP-81855.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASIC4
Protein Name amiloride-sensitive cation channel 4, pituitary
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000350786
InnateDB Gene IDBG-81849 (ASIC4)
Protein Structure
UniProt Annotation
Function Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity. {ECO:0000269PubMed:10852210}.
Subcellular Localization Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in pituitary gland. Weakly expressed in brain, vestibular system and organ of Corti. {ECO:0000269PubMed:10852210}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005272 sodium channel activity
GO:0015081 sodium ion transmembrane transporter activity
Biological Process
GO:0006810 transport
GO:0006814 sodium ion transport
GO:0034220 ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR001873 Na+ channel, amiloride-sensitive
PFAM PF00858
PRINTS PR01078
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96FT7
PhosphoSite PhosphoSite-Q96FT7
TrEMBL
UniProt Splice Variant
Entrez Gene 55515
UniGene
RefSeq XP_005246728
HUGO HGNC:21263
OMIM 606715
CCDS
HPRD 16231
IMGT
EMBL AC009955 AC053503 AC139723 AJ271643 AJ408881 AJ408882 AJ408883 AJ408884 BC010439 BC031812
GenPept AAH10439 AAH31812 AAY15054 CAB93980 CAC51338

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca