Version 5.4
Homo sapiens Gene: ATG4A
Summary
InnateDB Gene IDBG-81860.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATG4A
Gene Name autophagy related 4A, cysteine peptidase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000101844
Encoded Proteins
IDBP-81864
ATG4 autophagy related 4 homolog A (S. cerevisiae)
IDBP-81866
ATG4 autophagy related 4 homolog A (S. cerevisiae)
IDBP-81868
ATG4 autophagy related 4 homolog A (S. cerevisiae)
IDBP-81870
ATG4 autophagy related 4 homolog A (S. cerevisiae)
IDBP-240646
ATG4 autophagy related 4 homolog A (S. cerevisiae)
IDBP-378986
ATG4 autophagy related 4 homolog A (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:108091668-108154671
Strand Forward strand
Band q22.3
Transcripts
ENST00000372246 ENSP00000361320
ENST00000345734 ENSP00000298131
ENST00000343524 ENSP00000341833
ENST00000372232 ENSP00000361306
ENST00000394892 ENSP00000378354
ENST00000457035 ENSP00000416218
ENST00000474825
ENST00000489247
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006914 autophagy
GO:0015031 protein transport
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000079418
View Gene Order
ENSBTAG00000013724
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04140
Regulation of autophagy pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.8763
RefSeq NM_052936 NM_178270 XM_005262064
HUGO
OMIM
CCDS CCDS14538 CCDS14539
HPRD 06455
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca