Version 5.4
Homo sapiens Gene: EPHA4
Summary
InnateDB Gene IDBG-82135.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EPHA4
Gene Name EPH receptor A4
Synonyms HEK8; SEK; TYRO1
Species Homo sapiens
Ensembl Gene ENSG00000116106
Encoded Proteins
IDBP-82137
EPH receptor A4
IDBP-292990
EPH receptor A4
IDBP-292989
EPH receptor A4
IDBP-389109
EPH receptor A4
IDBP-389110
EPH receptor A4
IDBP-389111
EPH receptor A4
IDBP-389112
EPH receptor A4
IDBP-389113
EPH receptor A4
IDBP-389114
EPH receptor A4
IDBP-587321
EPH receptor A4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:221418027-221574202
Strand Reverse strand
Band q36.1
Transcripts
ENST00000281821 ENSP00000281821
ENST00000409938 ENSP00000386829
ENST00000409854 ENSP00000386276
ENST00000424339 ENSP00000408145
ENST00000443796 ENSP00000395917
ENST00000441679 ENSP00000401405
ENST00000415749 ENSP00000391517
ENST00000419964 ENSP00000410158
ENST00000434266 ENSP00000404089
ENST00000469354
ENST00000472696
ENST00000495693
ENST00000463446
ENST00000541600 ENSP00000444085
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 20 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005003 ephrin receptor activity
GO:0005004 GPI-linked ephrin receptor activity
GO:0005005 transmembrane-ephrin receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042731 PH domain binding
GO:0042802 identical protein binding
GO:0046875 ephrin receptor binding
GO:0097161 DH domain binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007155 cell adhesion
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007411 axon guidance
GO:0007628 adult walking behavior
GO:0008045 motor neuron axon guidance
GO:0008347 glial cell migration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021957 corticospinal tract morphogenesis
GO:0032314 regulation of Rac GTPase activity
GO:0032317 regulation of Rap GTPase activity
GO:0032319 regulation of Rho GTPase activity
GO:0043507 positive regulation of JUN kinase activity
GO:0046777 protein autophosphorylation
GO:0048013 ephrin receptor signaling pathway
GO:0048681 negative regulation of axon regeneration
GO:0048710 regulation of astrocyte differentiation
GO:0050770 regulation of axonogenesis
GO:0050775 positive regulation of dendrite morphogenesis
GO:0061001 regulation of dendritic spine morphogenesis
GO:0097155 fasciculation of sensory neuron axon
GO:0097156 fasciculation of motor neuron axon
GO:2001108 positive regulation of Rho guanyl-nucleotide exchange factor activity
Cellular Component
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0014069 postsynaptic density
GO:0030054 cell junction
GO:0030175 filopodium
GO:0030424 axon
GO:0030425 dendrite
GO:0031594 neuromuscular junction
GO:0031901 early endosome membrane
GO:0042995 cell projection
GO:0043197 dendritic spine
GO:0043204 perikaryon
GO:0043679 axon terminus
GO:0044295 axonal growth cone
GO:0044297 cell body
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026235
View Gene Order
ENSBTAG00000010030
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
REACT_228063
EPHA-mediated growth cone collapse pathway
REACT_228189
EPH-ephrin mediated repulsion of cells pathway
REACT_228170
EPH-Ephrin signaling pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
epha_fwdpathway
EPHA forward signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.371218 Hs.602500 Hs.622218
RefSeq NM_004438
HUGO
OMIM
CCDS CCDS2447
HPRD 03719
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca