Homo sapiens Gene: TNFSF8
Summary
InnateDB Gene IDBG-82328.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFSF8
Gene Name tumor necrosis factor (ligand) superfamily, member 8
Synonyms CD153; CD30L; CD30LG;
Species Homo sapiens
Ensembl Gene ENSG00000106952
Encoded Proteins
tumor necrosis factor (ligand) superfamily, member 8
tumor necrosis factor (ligand) superfamily, member 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin\'s and some non-Hodgkin\'s lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:114893343-114930595
Strand Reverse strand
Band q33.1
Transcripts
ENST00000223795 ENSP00000223795
ENST00000474301
ENST00000618336 ENSP00000484651
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0008283 cell proliferation
GO:0043374 CD8-positive, alpha-beta T cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050830 defense response to Gram-positive bacterium
Cellular Component
GO:0005615 extracellular space
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P32971
TrEMBL Q52M88
UniProt Splice Variant
Entrez Gene 944
UniGene Hs.494901 Hs.654445
RefSeq NM_001244 XM_006717325 NM_001252290
HUGO HGNC:11938
OMIM 603875
CCDS CCDS6810 CCDS75884
HPRD 04852
IMGT
EMBL AF006381 AF006382 AF006383 AF006384 AK313619 BC093630 BC111939 CH471090 L09753
GenPept AAA74594 AAB97877 AAH93630 AAI11940 BAG36381 EAW87433
RNA Seq Atlas 944