InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNFSF8

Summary

InnateDB Protein

IDBP-82330.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFSF8

Protein Name

tumor necrosis factor (ligand) superfamily, member 8

Synonyms

CD153; CD30L; CD30LG;

Species

Homo sapiens

Ensembl Protein

ENSP00000223795

InnateDB Gene

IDBG-82328 (TNFSF8)

Protein Structure

UniProt Annotation

Function

Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.

Subcellular Localization

Membrane; Single-pass type II membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0008283	cell proliferation
GO:0043374	CD8-positive, alpha-beta T cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050830	defense response to Gram-positive bacterium

Cellular Component

GO:0005615	extracellular space
GO:0005887	integral component of plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR006052 Tumour necrosis factor domain
IPR008983 Tumour necrosis factor-like domain
IPR021185 Tumour necrosis factor family protein, CD30 ligand type

PFAM

PF00229

PRINTS

PIRSF

PIRSF019548

SMART

SM00207

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt