Version 5.4
Homo sapiens Gene: MARCH5
Summary
InnateDB Gene IDBG-82450.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MARCH5
Gene Name membrane-associated ring finger (C3HC4) 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000198060
Encoded Proteins
IDBP-82452
membrane-associated ring finger (C3HC4) 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21625535
MARCH5 is a mitochondrial ubiquitin ligase that positively regulates TLR7 signalling. MARCH5 interacts with TANK to induce NFkB-mediated gene expression.
PMID 26246171
MARCH5 modulates MAVS-mediated antiviral signalling, preventing excessive immune reactions.
InnateDB Annotation from Orthologs
Summary
PMID 21625535
[Mus musculus] March5 is a mitochondrial ubiquitin ligase that positively regulates Tlr7 signalling. March5 interacts with Tank to induce NFkB-mediated gene expression.
PMID 26246171
[Mus musculus] March5 modulates Mavs-mediated antiviral signalling, preventing excessive immune reactions.
Entrez Gene
Summary MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2; MIM 608507) and DRP1 (DNM1L; MIM 603850) (Nakamura et al., 2006 [PubMed 16936636]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:92291163-92353964
Strand Forward strand
Band q23.32
Transcripts
ENST00000358935 ENSP00000351813
ENST00000467521
ENST00000462465
ENST00000492319
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
Experimentally validated
Total 31 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
GO:0051020 GTPase binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0045087 innate immune response (InnateDB)
GO:0051865 protein autoubiquitination
GO:0070585 protein localization to mitochondrion
GO:0090140 regulation of mitochondrial fission
GO:0090141 positive regulation of mitochondrial fission
GO:0090344 negative regulation of cell aging
Cellular Component
GO:0005741 mitochondrial outer membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023307
View Gene Order
ENSBTAG00000020981
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.573490 Hs.593359 Hs.594401
RefSeq NM_017824 XM_005269923
HUGO
OMIM
CCDS CCDS7420
HPRD 07909
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca