Homo sapiens Gene: PAK3
Summary
InnateDB Gene IDBG-82516.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAK3
Gene Name p21 protein (Cdc42/Rac)-activated kinase 3
Synonyms bPAK; CDKN1A; hPAK3; MRX30; MRX47; OPHN3; PAK3beta;
Species Homo sapiens
Ensembl Gene ENSG00000077264
Encoded Proteins
p21 protein (Cdc42/Rac)-activated kinase 3
p21 protein (Cdc42/Rac)-activated kinase 3
p21 protein (Cdc42/Rac)-activated kinase 3
p21 protein (Cdc42/Rac)-activated kinase 3
p21 protein (Cdc42/Rac)-activated kinase 3
p21 protein (Cdc42/Rac)-activated kinase 3
p21 protein (Cdc42/Rac)-activated kinase 3
p21 protein (Cdc42/Rac)-activated kinase 3
p21 protein (Cdc42/Rac)-activated kinase 3
p21 protein (Cdc42/Rac)-activated kinase 3
p21 protein (Cdc42/Rac)-activated kinase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:110944285-111227361
Strand Forward strand
Band q23
Transcripts
ENST00000372010 ENSP00000361080
ENST00000372007 ENSP00000361077
ENST00000360648 ENSP00000353864
ENST00000262836 ENSP00000262836
ENST00000446737 ENSP00000410853
ENST00000425146 ENSP00000401982
ENST00000429193 ENSP00000405642
ENST00000417227 ENSP00000389172
ENST00000484442
ENST00000519681 ENSP00000429113
ENST00000518291 ENSP00000428921
ENST00000487802
ENST00000620137 ENSP00000484798
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017048 Rho GTPase binding
GO:0017124 SH3 domain binding
GO:0046872 metal ion binding
GO:0051020 GTPase binding
Biological Process
GO:0000165 MAPK cascade
GO:0000187 activation of MAPK activity
GO:0006468 protein phosphorylation
GO:0007015 actin filament organization
GO:0007409 axonogenesis
GO:0010975 regulation of neuron projection development
GO:0016358 dendrite development
GO:0023014 signal transduction by phosphorylation
GO:0030833 regulation of actin filament polymerization
GO:0043525 positive regulation of neuron apoptotic process
GO:0050808 synapse organization
GO:0060997 dendritic spine morphogenesis
GO:0061003 positive regulation of dendritic spine morphogenesis
GO:2000573 positive regulation of DNA biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Developmental Biology pathway
TCR signaling pathway
Semaphorin interactions pathway
Signaling by VEGF pathway
Innate Immune System pathway
VEGFR2 mediated vascular permeability pathway
Axon guidance pathway
Fc epsilon receptor (FCERI) signaling pathway
Activation of Rac pathway
Signal Transduction pathway
CD28 co-stimulation pathway
CD28 dependent Vav1 pathway pathway
Sema3A PAK dependent Axon repulsion pathway
Adaptive Immune System pathway
Immune System pathway
Ephrin signaling pathway
VEGFA-VEGFR2 Pathway pathway
EPH-Ephrin signaling pathway
Signaling by Robo receptor pathway
Generation of second messenger molecules pathway
Costimulation by the CD28 family pathway
FCERI mediated MAPK activation pathway
KEGG
ErbB signaling pathway pathway
Axon guidance pathway
Focal adhesion pathway
T cell receptor signaling pathway pathway
Regulation of actin cytoskeleton pathway
Renal cell carcinoma pathway
INOH
PID BIOCARTA
Agrin in postsynaptic differentiation [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.656789
RefSeq NM_001128166 NM_001128167 NM_001128168 NM_001128172 NM_001128173 NM_002578 XM_005262133 XM_006724656
HUGO
OMIM
CCDS CCDS14554 CCDS48151 CCDS48152 CCDS48153
HPRD 02142
IMGT
EMBL
GenPept
RNA Seq Atlas