InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PAK3

Summary

InnateDB Gene

IDBG-82516.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PAK3

Gene Name

p21 protein (Cdc42/Rac)-activated kinase 3

Synonyms

bPAK; CDKN1A; hPAK3; MRX30; MRX47; OPHN3; PAK3beta

Species

Homo sapiens

Ensembl Gene

ENSG00000077264

Encoded Proteins

IDBP-82518

p21 protein (Cdc42/Rac)-activated kinase 3

IDBP-82520

p21 protein (Cdc42/Rac)-activated kinase 3

IDBP-82522

p21 protein (Cdc42/Rac)-activated kinase 3

IDBP-82524

p21 protein (Cdc42/Rac)-activated kinase 3

IDBP-379299

p21 protein (Cdc42/Rac)-activated kinase 3

IDBP-379300

p21 protein (Cdc42/Rac)-activated kinase 3

IDBP-379306

p21 protein (Cdc42/Rac)-activated kinase 3

IDBP-379311

p21 protein (Cdc42/Rac)-activated kinase 3

IDBP-473794

p21 protein (Cdc42/Rac)-activated kinase 3

IDBP-480955

p21 protein (Cdc42/Rac)-activated kinase 3

IDBP-806830

p21 protein (Cdc42/Rac)-activated kinase 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:110944285-111227361

Strand

Forward strand

Band

q23

Transcripts

ENST00000372010	ENSP00000361080
ENST00000372007	ENSP00000361077
ENST00000360648	ENSP00000353864
ENST00000262836	ENSP00000262836
ENST00000446737	ENSP00000410853
ENST00000425146	ENSP00000401982
ENST00000429193	ENSP00000405642
ENST00000417227	ENSP00000389172
ENST00000484442
ENST00000519681	ENSP00000429113
ENST00000518291	ENSP00000428921
ENST00000487802
ENST00000620137	ENSP00000484798

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004708	MAP kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017048	Rho GTPase binding
GO:0017124	SH3 domain binding
GO:0046872	metal ion binding
GO:0051020	GTPase binding

Biological Process

GO:0000165	MAPK cascade
GO:0000187	activation of MAPK activity
GO:0006468	protein phosphorylation
GO:0007015	actin filament organization
GO:0007409	axonogenesis
GO:0010975	regulation of neuron projection development
GO:0016358	dendrite development
GO:0023014	signal transduction by phosphorylation
GO:0030833	regulation of actin filament polymerization
GO:0043525	positive regulation of neuron apoptotic process
GO:0050808	synapse organization
GO:0060997	dendritic spine morphogenesis
GO:0061003	positive regulation of dendritic spine morphogenesis
GO:2000573	positive regulation of DNA biosynthetic process

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000031284

View Gene Order

ENSBTAG00000015670

Not yet available

Pathways

NETPATH

REACTOME

REACT_12623

Generation of second messenger molecules pathway

REACT_19238

CD28 dependent Vav1 pathway pathway

REACT_19183

CD28 co-stimulation pathway

REACT_19344

Costimulation by the CD28 family pathway

REACT_19236

Sema3A PAK dependent Axon repulsion pathway

REACT_19226

Activation of Rac pathway

REACT_19351

Signaling by Robo receptor pathway

REACT_111045

Developmental Biology pathway

REACT_12526

TCR signaling pathway

REACT_19271

Semaphorin interactions pathway

REACT_12529

Signaling by VEGF pathway

REACT_6802

Innate Immune System pathway

REACT_228016

VEGFR2 mediated vascular permeability pathway

REACT_18266

Axon guidance pathway

REACT_163936

Fc epsilon receptor (FCERI) signaling pathway

REACT_111102

Signal Transduction pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_228226

Ephrin signaling pathway

REACT_228166

VEGFA-VEGFR2 Pathway pathway

REACT_228170

EPH-Ephrin signaling pathway

REACT_163701

FCERI mediated MAPK activation pathway

KEGG

hsa04810

Regulation of actin cytoskeleton pathway

hsa04012

ErbB signaling pathway pathway

hsa05211

Renal cell carcinoma pathway

hsa04360

Axon guidance pathway

hsa04510

Focal adhesion pathway

hsa04660

T cell receptor signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

O75914

TrEMBL

UniProt Splice Variant

Entrez Gene

5063

UniGene

Hs.656789

RefSeq

NM_001128166 NM_001128167 NM_001128168 NM_001128172 NM_001128173 NM_002578 XM_005262133 XM_006724656

HUGO

HGNC:8592

OMIM

300142

CCDS

CCDS48152 CCDS14554 CCDS48151 CCDS48153

HPRD

02142

IMGT

EMBL

AB102251 AB102252 AB102253 AB102254 AB102255 AB102256 AB102257 AB102258 AB102259 AB102260 AB102261 AB102262 AB102263 AB102264 AB102265 AB102266 AB102267 AB102268 AB102269 AB102270 AB102281 AB102282 AB102283 AB102284 AB102285 AB102286 AB102287 AB102288 AB102289 AB102290 AB102291 AB102292 AB102293 AB102294 AB102295 AB102296 AB102297 AB102298 AB102299 AB102300 AB102659 AF068864 AF155651 AK290504 AL031117 AL117326 AL356578 AL357774 AM943850 AM943851 AM943852 CH471120

GenPept

AAC36097 AAF67008 BAC80750 BAC80751 BAC80752 BAC80753 BAC80754 BAC80755 BAC80756 BAC80757 BAC80758 BAC80759 BAC80760 BAC80761 BAC80762 BAC80763 BAC80764 BAC80765 BAC80766 BAC80767 BAC80768 BAC80769 BAC80780 BAC80781 BAC80782 BAC80783 BAC80784 BAC80785 BAC80786 BAC80787 BAC80788 BAC80789 BAC80790 BAC80791 BAC80792 BAC80793 BAC80794 BAC80795 BAC80796 BAC80797 BAC80798 BAC80799 BAC81128 BAF83193 CAI40843 CAI40844 CAI43157 CAI43158 CAI43167 CAI43168 CAQ16016 CAQ16017 CAQ16018 EAX02654

RNA Seq Atlas

5063