Homo sapiens Gene: STX16
Summary
InnateDB Gene IDBG-82615.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STX16
Gene Name syntaxin 16
Synonyms SYN16;
Species Homo sapiens
Ensembl Gene ENSG00000124222
Encoded Proteins
syntaxin 16
syntaxin 16
syntaxin 16
syntaxin 16
syntaxin 16
syntaxin 16
syntaxin 16
syntaxin 16
syntaxin 16
syntaxin 16
syntaxin 16
syntaxin 16
syntaxin 16
syntaxin 16
syntaxin 16
syntaxin 16
syntaxin 16
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for V-SNARES (vesicle-SNAP receptors) permitting specific synaptic vesicle docking and fusion. A microdeletion in the region of chromosome 20 where this gene is located has been associated with pseudohypoparathyroidism type Ib. Multiple transcript variants have been found for this gene. Read-through transcription also exists between this gene and the neighboring downstream aminopeptidase-like 1 (NPEPL1) gene. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:58651253-58679526
Strand Forward strand
Band q13.32
Transcripts
ENST00000355957 ENSP00000348229
ENST00000371141 ENSP00000360183
ENST00000361830 ENSP00000354445
ENST00000358029 ENSP00000350723
ENST00000371132 ENSP00000360173
ENST00000361770 ENSP00000355408
ENST00000359617 ENSP00000352634
ENST00000312283 ENSP00000312086
ENST00000458280 ENSP00000388348
ENST00000412911 ENSP00000416852
ENST00000438253 ENSP00000401801
ENST00000460655 ENSP00000435118
ENST00000476384 ENSP00000437209
ENST00000483434 ENSP00000432823
ENST00000496117
ENST00000490700
ENST00000496003
ENST00000467096 ENSP00000434369
ENST00000464640 ENSP00000432414
ENST00000493301 ENSP00000436667
ENST00000468590
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 5 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005484 SNAP receptor activity
GO:0005515 protein binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006891 intra-Golgi vesicle-mediated transport
GO:0016192 vesicle-mediated transport
GO:0042147 retrograde transport, endosome to Golgi
Cellular Component
GO:0000139 Golgi membrane
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031201 SNARE complex
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
SNARE interactions in vesicular transport pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O14662
TrEMBL B4DJX9 B7ZBM4 B7ZBM5 F8W9Z6
UniProt Splice Variant
Entrez Gene 8675
UniGene Hs.307913 Hs.595479 Hs.608757 Hs.610411
RefSeq NM_001001433 NM_001134772 NM_001134773 NM_001204868 NM_003763
HUGO HGNC:11431
OMIM 603666
CCDS CCDS13468 CCDS13469 CCDS46619 CCDS46620 CCDS56199
HPRD 04718
IMGT
EMBL AF008935 AF008936 AF008937 AF038897 AK296282 AK316547 AL050327 AL139349 BC019042 BC073876 BX396221 CH471077
GenPept AAB69282 AAB69283 AAB69284 AAC05647 AAH19042 AAH73876 BAG58991 BAH14918 CAI23277 CAI23278 CAI23279 CAM28341 CAX14989 CAX14990 CAX14991 CAX14992 EAW75481 EAW75482 EAW75483 EAW75484 EAW75485 EAW75486 EAW75487
RNA Seq Atlas 8675