InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STX16

Summary

InnateDB Protein

IDBP-82617.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STX16

Protein Name

syntaxin 16

Synonyms

SYN16;

Species

Homo sapiens

Ensembl Protein

ENSP00000348229

InnateDB Gene

IDBG-82615 (STX16)

Protein Structure

UniProt Annotation

Function

SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269PubMed:18195106}.

Subcellular Localization

Golgi apparatus membrane; Single-pass type IV membrane protein.Isoform C: Cytoplasm.

Disease Associations

Pseudohypoparathyroidism 1B (PHP1B) [MIM:603233]: A disorder characterized by end-organ resistance to parathyroid hormone, hypocalcemia and hyperphosphatemia. Patients affected with PHP1B lack developmental defects characteristic of Albright hereditary osteodystrophy, and typically show no other endocrine abnormalities besides resistance to PTH. {ECO:0000269PubMed:14561710, ECO:0000269PubMed:15800843}. Note=The gene represented in this entry is involved in disease pathogenesis. Microdeletions involving STX16 can cause loss of methylation at exon A/B of GNAS, resulting in PHP1B.

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	5 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005484	SNAP receptor activity
GO:0005515	protein binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006891	intra-Golgi vesicle-mediated transport
GO:0016192	vesicle-mediated transport
GO:0042147	retrograde transport, endosome to Golgi

Cellular Component

GO:0000139	Golgi membrane
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031201	SNARE complex
GO:0043231	intracellular membrane-bounded organelle