Homo sapiens Gene: DIS3L2
Summary
InnateDB Gene IDBG-83173.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DIS3L2
Gene Name DIS3 mitotic control homolog (S. cerevisiae)-like 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000144535
Encoded Proteins
DIS3 mitotic control homolog (S. cerevisiae)-like 2
DIS3 mitotic control homolog (S. cerevisiae)-like 2
DIS3 mitotic control homolog (S. cerevisiae)-like 2
DIS3 mitotic control homolog (S. cerevisiae)-like 2
DIS3 mitotic control homolog (S. cerevisiae)-like 2
DIS3 mitotic control homolog (S. cerevisiae)-like 2
DIS3 mitotic control homolog (S. cerevisiae)-like 2
DIS3 mitotic control homolog (S. cerevisiae)-like 2
DIS3 mitotic control homolog (S. cerevisiae)-like 2
DIS3 mitotic control homolog (S. cerevisiae)-like 2
DIS3 mitotic control homolog (S. cerevisiae)-like 2
DIS3 mitotic control homolog (S. cerevisiae)-like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:231961245-232344350
Strand Forward strand
Band q37.1
Transcripts
ENST00000273009 ENSP00000273009
ENST00000325385 ENSP00000315569
ENST00000390005 ENSP00000374655
ENST00000409307 ENSP00000386799
ENST00000409401 ENSP00000386594
ENST00000445090 ENSP00000388999
ENST00000441279 ENSP00000390467
ENST00000433430 ENSP00000391175
ENST00000424049 ENSP00000415419
ENST00000434477 ENSP00000392754
ENST00000418143 ENSP00000401700
ENST00000417808 ENSP00000408764
ENST00000429283
ENST00000464554
ENST00000470087
ENST00000498319
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000175 3'-5'-exoribonuclease activity
GO:0003723 RNA binding
GO:0004540 ribonuclease activity
GO:0005515 protein binding
Biological Process
GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic
GO:0007067 mitotic nuclear division
GO:0008285 negative regulation of cell proliferation
GO:0010587 miRNA catabolic process
GO:0019827 stem cell maintenance
GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
GO:0051306 mitotic sister chromatid separation
GO:0090501 RNA phosphodiester bond hydrolysis
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
GO:1990074 polyuridylation-dependent mRNA catabolic process
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005737 cytoplasm
GO:0005844 polysome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 129563
UniGene Hs.601605 Hs.732236
RefSeq NM_001257281 NM_001257282 NM_152383
HUGO HGNC:28648
OMIM 614184
CCDS CCDS42834 CCDS58752 CCDS58753
HPRD 14619
IMGT
EMBL
GenPept
RNA Seq Atlas 129563