Version 5.4
Homo sapiens Gene: EIF4E2
Summary
InnateDB Gene IDBG-83304.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF4E2
Gene Name eukaryotic translation initiation factor 4E family member 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000135930
Encoded Proteins
IDBP-83306
eukaryotic translation initiation factor 4E family member 2
IDBP-292904
eukaryotic translation initiation factor 4E family member 2
IDBP-292905
eukaryotic translation initiation factor 4E family member 2
IDBP-292906
eukaryotic translation initiation factor 4E family member 2
IDBP-292902
eukaryotic translation initiation factor 4E family member 2
IDBP-292895
eukaryotic translation initiation factor 4E family member 2
IDBP-292896
eukaryotic translation initiation factor 4E family member 2
IDBP-389307
eukaryotic translation initiation factor 4E family member 2
IDBP-389309
eukaryotic translation initiation factor 4E family member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 2:232550052-232583644
Strand Forward strand
Band q37.1
Transcripts
ENST00000258416 ENSP00000258416
ENST00000409098 ENSP00000386996
ENST00000409394 ENSP00000386983
ENST00000409514 ENSP00000387336
ENST00000409322 ENSP00000386424
ENST00000409167 ENSP00000387328
ENST00000409495 ENSP00000386876
ENST00000454501 ENSP00000390904
ENST00000444113 ENSP00000389578
ENST00000463074
ENST00000498242
ENST00000479834
ENST00000478878
ENST00000459714
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 39 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000339 RNA cap binding
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0008135 translation factor activity, nucleic acid binding
GO:0031625 ubiquitin protein ligase binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006413 translational initiation
GO:0017148 negative regulation of translation
GO:0019221 cytokine-mediated signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005845 mRNA cap binding complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026254
View Gene Order
ENSBTAG00000010598
Not yet available
Pathways
NETPATH
REACTOME
REACT_115831
ISG15 antiviral mechanism pathway
REACT_115676
Antiviral mechanism by IFN-stimulated genes pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_6900
Immune System pathway
KEGG
hsa04150
mTOR signaling pathway pathway
hsa04910
Insulin signaling pathway pathway
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.292026 Hs.598884
RefSeq NM_001276336 NM_001276337 NM_001282958 NM_004846
HUGO
OMIM
CCDS CCDS2496 CCDS63158 CCDS63159 CCDS74671
HPRD 05798
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca