InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: INPP5D

Summary

InnateDB Gene

IDBG-83441.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

INPP5D

Gene Name

inositol polyphosphate-5-phosphatase, 145kDa

Synonyms

hp51CN; p150Ship; SHIP; SHIP-1; SHIP1; SIP-145

Species

Homo sapiens

Ensembl Gene

ENSG00000168918

Encoded Proteins

IDBP-83443

inositol polyphosphate-5-phosphatase, 145kDa

IDBP-389361

inositol polyphosphate-5-phosphatase, 145kDa

IDBP-389362

inositol polyphosphate-5-phosphatase, 145kDa

IDBP-389364

inositol polyphosphate-5-phosphatase, 145kDa

IDBP-813021

inositol polyphosphate-5-phosphatase, 145kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20100929

INPP5D (SHIP-1) is a critical negative regulator of IFN-beta production downstream of TLR3 through the regulation of TBK1 localization and activity.

PMID 20154203

INPP5D is a negative regulator of GM-CSF-derived dendritic cell (DC) generation but a positive regulator of GM-CSF-derived DC maturation and function.

InnateDB Annotation from Orthologs

Summary

PMID 20385881

[Mus musculus] Inpp5d promotes while the Lyn/PI3K module negatively regulates activation in murine macrophages viaTlr2 and Tlr4 receptors.

Entrez Gene

Summary

This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5\' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:233059967-233207903

Strand

Forward strand

Band

q37.1

Transcripts

ENST00000359570	ENSP00000352575
ENST00000451407
ENST00000415617	ENSP00000397421
ENST00000445964	ENSP00000405338
ENST00000417661	ENSP00000414835
ENST00000467393
ENST00000474278
ENST00000496402
ENST00000493078
ENST00000472517
ENST00000493632
ENST00000480983
ENST00000465281
ENST00000491070	ENSP00000473280

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	58 [view]
Protein-Protein	58 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004445	inositol-polyphosphate 5-phosphatase activity
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0034594	phosphatidylinositol trisphosphate phosphatase activity
GO:0051425	PTB domain binding

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0006796	phosphate-containing compound metabolic process
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0008285	negative regulation of cell proliferation
GO:0008340	determination of adult lifespan
GO:0009968	negative regulation of signal transduction
GO:0016064	immunoglobulin mediated immune response
GO:0016311	dephosphorylation
GO:0030853	negative regulation of granulocyte differentiation
GO:0030889	negative regulation of B cell proliferation
GO:0035556	intracellular signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0043647	inositol phosphate metabolic process
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045409	negative regulation of interleukin-6 biosynthetic process
GO:0045579	positive regulation of B cell differentiation
GO:0045621	positive regulation of lymphocyte differentiation
GO:0045648	positive regulation of erythrocyte differentiation
GO:0045656	negative regulation of monocyte differentiation
GO:0045659	negative regulation of neutrophil differentiation
GO:0045671	negative regulation of osteoclast differentiation
GO:0045779	negative regulation of bone resorption
GO:0046856	phosphatidylinositol dephosphorylation
GO:0050777	negative regulation of immune response
GO:0050852	T cell receptor signaling pathway
GO:0050869	negative regulation of B cell activation
GO:0050900	leukocyte migration