InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: INPP5D

Summary

InnateDB Protein

IDBP-389362.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

INPP5D

Protein Name

inositol polyphosphate-5-phosphatase, 145kDa

Synonyms

hp51CN; p150Ship; SHIP; SHIP-1; SHIP1; SIP-145;

Species

Homo sapiens

Ensembl Protein

ENSP00000405338

InnateDB Gene

IDBG-83441 (INPP5D)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	58 [view]
Protein-Protein	58 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004445	inositol-polyphosphate 5-phosphatase activity
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0034594	phosphatidylinositol trisphosphate phosphatase activity
GO:0051425	PTB domain binding

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0006796	phosphate-containing compound metabolic process
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0008285	negative regulation of cell proliferation
GO:0008340	determination of adult lifespan
GO:0009968	negative regulation of signal transduction
GO:0016064	immunoglobulin mediated immune response
GO:0016311	dephosphorylation
GO:0030853	negative regulation of granulocyte differentiation
GO:0030889	negative regulation of B cell proliferation
GO:0035556	intracellular signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0043647	inositol phosphate metabolic process
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045409	negative regulation of interleukin-6 biosynthetic process
GO:0045579	positive regulation of B cell differentiation
GO:0045621	positive regulation of lymphocyte differentiation
GO:0045648	positive regulation of erythrocyte differentiation
GO:0045656	negative regulation of monocyte differentiation
GO:0045659	negative regulation of neutrophil differentiation
GO:0045671	negative regulation of osteoclast differentiation
GO:0045779	negative regulation of bone resorption
GO:0046856	phosphatidylinositol dephosphorylation
GO:0050777	negative regulation of immune response
GO:0050852	T cell receptor signaling pathway
GO:0050869	negative regulation of B cell activation
GO:0050900	leukocyte migration