Version 5.4
Homo sapiens Gene: PHACTR3
Summary
InnateDB Gene IDBG-83464.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PHACTR3
Gene Name phosphatase and actin regulator 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000087495
Encoded Proteins
IDBP-83466
phosphatase and actin regulator 3
IDBP-83468
phosphatase and actin regulator 3
IDBP-83470
phosphatase and actin regulator 3
IDBP-83472
phosphatase and actin regulator 3
IDBP-239136
phosphatase and actin regulator 3
IDBP-379774
phosphatase and actin regulator 3
IDBP-599426
phosphatase and actin regulator 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is associated with the nuclear scaffold in proliferating cells. It was found to bind to the catalytic subunit of protein phosphatase-1 (PP1) and inhibit PP1 activity, suggesting that this protein may function as a regulatory subunit of PP1. Alternative splicing at this locus results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:59577509-59847711
Strand Forward strand
Band q13.32
Transcripts
ENST00000359926 ENSP00000353002
ENST00000355648 ENSP00000347866
ENST00000361300 ENSP00000354555
ENST00000371015 ENSP00000360054
ENST00000395636 ENSP00000378998
ENST00000434923 ENSP00000390915
ENST00000492611
ENST00000473657
ENST00000541461 ENSP00000442483
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0004864 protein phosphatase inhibitor activity
Biological Process
GO:0043086 negative regulation of catalytic activity
Cellular Component
GO:0005634 nucleus
GO:0016363 nuclear matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027525
View Gene Order
ENSBTAG00000015080
Not yet available
Cross-References
SwissProt Q96KR7
TrEMBL
UniProt Splice Variant
Entrez Gene 116154
UniGene Hs.473218 Hs.594895 Hs.630982 Hs.631200
RefSeq NM_183244 NM_001199505 NM_001199506 NM_001281507 NM_080672 NM_183246
HUGO HGNC:15833
OMIM 608725
CCDS CCDS42895 CCDS13480 CCDS13481 CCDS56202
HPRD 10571
IMGT
EMBL AB098521 AB098522 AJ311122 AJ617581 AK098788 AK314493 AK316047 AL121908 AL357503 BC108303 BC117362 BC117364 CH471077
GenPept AAI08304 AAI17363 AAI17365 BAC82348 BAC82349 BAG37093 BAH14418 CAC67489 CAF04087 CAI22517 CAI22518 CAI23227 CAI23228 CAI23229 CAM28339 EAW75428 EAW75429 EAW75430
RNA Seq Atlas 116154

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca