Homo sapiens Gene: MGAT3
Summary
InnateDB Gene IDBG-8348.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MGAT3
Gene Name mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
Synonyms GNT-III; GNT3;
Species Homo sapiens
Ensembl Gene ENSG00000128268
Encoded Proteins
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. The enzyme encoded by this gene transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:39457344-39492194
Strand Forward strand
Band q13.1
Transcripts
ENST00000341184 ENSP00000345270
ENST00000429402 ENSP00000416226
ENST00000418314 ENSP00000408075
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003830 beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
Biological Process
GO:0006487 protein N-linked glycosylation
GO:0018279 protein N-linked glycosylation via asparagine
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Post-translational protein modification pathway
N-glycan antennae elongation in the medial/trans-Golgi pathway
Asparagine N-linked glycosylation pathway
Metabolism of proteins pathway
Reactions specific to the hybrid N-glycan synthesis pathway pathway
Transport to the Golgi and subsequent modification pathway
KEGG
N-Glycan biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Stabilization and expansion of the E-cadherin adherens junction
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.276808
RefSeq NM_001098270 NM_002409 XM_005261608 XM_005261609 XM_006724252
HUGO
OMIM
CCDS CCDS13994
HPRD 07058
IMGT
EMBL
GenPept
RNA Seq Atlas