InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MGAT3

Summary

InnateDB Protein

IDBP-96517.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MGAT3

Protein Name

mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase

Synonyms

GNT-III; GNT3;

Species

Homo sapiens

Ensembl Protein

ENSP00000345270

InnateDB Gene

IDBG-8348 (MGAT3)

Protein Structure

UniProt Annotation

Function

It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides.

Subcellular Localization

Golgi apparatus membrane; Single-pass type II membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003830	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity

Biological Process

GO:0006487	protein N-linked glycosylation
GO:0018279	protein N-linked glycosylation via asparagine
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process