InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PIK3AP1

Summary

InnateDB Gene

IDBG-83923.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIK3AP1

Gene Name

phosphoinositide-3-kinase adaptor protein 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000155629

Encoded Proteins

IDBP-83927

phosphoinositide-3-kinase adaptor protein 1

IDBP-83929

phosphoinositide-3-kinase adaptor protein 1

IDBP-83931

phosphoinositide-3-kinase adaptor protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20728433

PIK3AP1 acts as a negative regulator of TLR-induced production of IL6 and IL10 in macrophages in response to LPS stimulation. (Demonstrated in murine model)

InnateDB Annotation from Orthologs

Summary

PMID 20728433

[Mus musculus] Pik3ap1 acts as a negative regulator of TLR-induced production of IL6 and IL10 in macrophages in response to LPS stimulation.

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:96593312-96720514

Strand

Reverse strand

Band

q24.1

Transcripts

ENST00000339364	ENSP00000339826
ENST00000371110	ENSP00000360151
ENST00000371109	ENSP00000360150
ENST00000467625
ENST00000489982
ENST00000468783

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	7 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding
GO:0042802	identical protein binding

Biological Process

GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0034122	negative regulation of toll-like receptor signaling pathway
GO:0034123	positive regulation of toll-like receptor signaling pathway
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034154	toll-like receptor 7 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0050727	regulation of inflammatory response

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000025017

View Gene Order

ENSBTAG00000019872

Not yet available

Pathways

NETPATH

NetPath_11

TCR pathway

NetPath_12

BCR pathway

REACTOME

REACT_118700

Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_118773

Signaling by the B Cell Receptor (BCR) pathway

KEGG

hsa04662

B cell receptor signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.310456

RefSeq

NM_152309 XM_005269498 XM_005269499

HUGO

OMIM

CCDS

CCDS31259

HPRD

06401

IMGT

EMBL

GenPept

RNA Seq Atlas