Version 5.4
Homo sapiens Gene: KLHL17
Summary
InnateDB Gene IDBG-84242.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLHL17
Gene Name kelch-like 17 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000187961
Encoded Proteins
IDBP-84246
kelch-like 17 (Drosophila)
IDBP-721873
IDBP-811286
kelch-like family member 17
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is expressed in neurons of most regions of the brain. It contains an N-terminal BTB domain, which mediates dimerization of the protein, and a C-terminal Kelch domain, which mediates binding to F-actin. This protein may play a key role in the regulation of actin-based neuronal function. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:960587-965715
Strand Forward strand
Band p36.33
Transcripts
ENST00000338591 ENSP00000343930
ENST00000463212
ENST00000466300 ENSP00000463694
ENST00000481067
ENST00000622660 ENSP00000479477
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031208 POZ domain binding
GO:0032947 protein complex scaffold
GO:0051015 actin filament binding
Biological Process
GO:0007420 brain development
GO:0016567 protein ubiquitination
GO:0030036 actin cytoskeleton organization
Cellular Component
GO:0005615 extracellular space
GO:0014069 postsynaptic density
GO:0015629 actin cytoskeleton
GO:0030054 cell junction
GO:0032839 dendrite cytoplasm
GO:0043025 neuronal cell body
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000078484
View Gene Order
ENSBTAG00000013813
Not yet available
Cross-References
SwissProt Q6TDP4
TrEMBL B3KXL7 Q0VGE6
UniProt Splice Variant
Entrez Gene 339451
UniGene Hs.109212 Hs.605959
RefSeq NM_198317
HUGO HGNC:24023
OMIM
CCDS CCDS30550
HPRD
IMGT
EMBL AK127585 AL645608 AY423763 BC105742 CH471183
GenPept AAI05743 AAR03710 BAG54529 CAI15569 EAW56302
RNA Seq Atlas 339451

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca