InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KLHL17

Summary

InnateDB Protein

IDBP-84246.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLHL17

Protein Name

kelch-like 17 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000343930

InnateDB Gene

IDBG-84242 (KLHL17)

Protein Structure

UniProt Annotation

Function

Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity). {ECO:0000250}.

Subcellular Localization

Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Postsynaptic density. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031208	POZ domain binding
GO:0032947	protein complex scaffold
GO:0051015	actin filament binding

Biological Process

GO:0007420	brain development
GO:0016567	protein ubiquitination
GO:0030036	actin cytoskeleton organization

Cellular Component

GO:0005615	extracellular space
GO:0014069	postsynaptic density
GO:0015629	actin cytoskeleton
GO:0030054	cell junction
GO:0032839	dendrite cytoplasm
GO:0043025	neuronal cell body
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000210 BTB/POZ-like
IPR006652 Kelch repeat type 1
IPR011333 BTB/POZ fold
IPR011498 Kelch repeat type 2
IPR011705 BTB/Kelch-associated
IPR013069 BTB/POZ
IPR017096 Kelch-like protein, gigaxonin type

PFAM

PF01344
PF07646
PF07707
PF00651

PRINTS

PIRSF

PIRSF037037

SMART

SM00225
SM00612
SM00875

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt