Homo sapiens Gene: HRH3
Summary
InnateDB Gene IDBG-84247.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HRH3
Gene Name histamine receptor H3
Synonyms GPCR97; HH3R;
Species Homo sapiens
Ensembl Gene ENSG00000101180
Encoded Proteins
histamine receptor H3
histamine receptor H3
histamine receptor H3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:62214970-62220267
Strand Reverse strand
Band q13.33
Transcripts
ENST00000340177 ENSP00000342560
ENST00000317393 ENSP00000321482
ENST00000611492 ENSP00000482567
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004969 histamine receptor activity
GO:0008144 drug binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007269 neurotransmitter secretion
GO:0007420 brain development
GO:0007612 learning
GO:0007613 memory
GO:0014050 negative regulation of glutamate secretion
GO:0014053 negative regulation of gamma-aminobutyric acid secretion
GO:0014061 regulation of norepinephrine secretion
GO:0014063 negative regulation of serotonin secretion
GO:0014070 response to organic cyclic compound
GO:0042755 eating behavior
GO:0042756 drinking behavior
GO:0045776 negative regulation of blood pressure
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050890 cognition
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0043005 neuron projection
GO:0043209 myelin sheath
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Amine ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
GPCR ligand binding pathway
Histamine receptors pathway
KEGG
Neuroactive ligand-receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9Y5N1
TrEMBL Q8NCH4
UniProt Splice Variant
Entrez Gene 11255
UniGene Hs.251399
RefSeq NM_007232
HUGO HGNC:5184
OMIM 604525
CCDS CCDS13493
HPRD
IMGT
EMBL AB019000 AB045369 AF140538 AF363791 AJ278250 AJ296652 AK074730 AL078633 BC096840
GenPept AAD38151 AAH96840 AAK50040 BAB17030 BAB20090 BAC11167 CAC04014 CAC39434 CAC51025
RNA Seq Atlas 11255