InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HRH3

Summary

InnateDB Protein

IDBP-84249.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HRH3

Protein Name

histamine receptor H3

Synonyms

GPCR97; HH3R;

Species

Homo sapiens

Ensembl Protein

ENSP00000342560

InnateDB Gene

IDBG-84247 (HRH3)

Protein Structure

UniProt Annotation

Function

The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed predominantly in the CNS, with the greatest expression in the thalamus and caudate nucleus. The various isoforms are mainly coexpressed in brain, but their relative expression level varies in a region-specific manner. Isoform 3 and isoform 7 are highly expressed in the thalamus, caudate nucleus and cerebellum while isoform 5 and isoform 6 show a poor expression. Isoform 5 and isoform 6 show a high expression in the amygdala, substantia nigra, cerebral cortex and hypothalamus. Isoform 7 is not found in hypothalamus or substantia nigra.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004969	histamine receptor activity
GO:0008144	drug binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007269	neurotransmitter secretion
GO:0007420	brain development
GO:0007612	learning
GO:0007613	memory
GO:0014050	negative regulation of glutamate secretion
GO:0014053	negative regulation of gamma-aminobutyric acid secretion
GO:0014061	regulation of norepinephrine secretion
GO:0014063	negative regulation of serotonin secretion
GO:0014070	response to organic cyclic compound
GO:0042755	eating behavior
GO:0042756	drinking behavior
GO:0045776	negative regulation of blood pressure
GO:0050679	positive regulation of epithelial cell proliferation
GO:0050890	cognition

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0043005	neuron projection
GO:0043209	myelin sheath

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000995 Muscarinic acetylcholine receptor family
IPR003980 Histamine H3 receptor
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR00243
PR01471

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y5N1